Citrate: How to Get Started and What, When, and How to Monitor?

Overview

Journal J Transl Int Med

Publisher Sciendo

Specialty General Medicine

Date 2018 Nov 15

PMID 30425947

Citations 5

Authors

Patrick M Honore

David De Bels

Thierry Preseau

Sebastien Redant

Herbert D Spapen

Affiliations

Soon will be listed here.

Abstract

In most of the case, regional citrate anticoagulation is using diluted citrate around 1% depending on the types used in clinical practice. Diluted citrate is much more safer when compared to highly concentrated citrate around 4% or even more. In clinical practice, trisodium citrate is used in high concentration (around 30%) as a bactericidal agent with anticoagulant properties for locking deep venous catheters used in hemodialysis (HD; close to 25-30% of citrate). In this review article, buffer and anticoagulant potential of citrate are discussed during renal replacement therapy in critically ill patients with particular focus on the practical approach at the bedside.

Citing Articles

Safety of Citrate Anticoagulation in CKRT: Monocentric Experience of a Dynamic Protocol of Calcium Monitoring.

Nalesso F, Bettin E, Bogo M, Cacciapuoti M, Cattarin L, Scaparrotta G J Clin Med. 2023; 12(16).

PMID: 37629242 PMC: 10455350. DOI: 10.3390/jcm12165201.

Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus.

Liu S, Xu S, Yin L, Yang T, Jin K, Zhang Q Mil Med Res. 2023; 10(1):23.

PMID: 37248514 PMC: 10226261. DOI: 10.1186/s40779-023-00457-9.

Negative calcium balance despite normal plasma ionized calcium concentrations during citrate anticoagulated continuous venovenous hemofiltration (CVVH) in ICU patients.

de Jonge E, van der Vooren M, Gillis J, Del Prado M, Wigbers J, Bakhshi-Raiez F J Nephrol. 2022; 36(4):1019-1026.

PMID: 36342643 PMC: 10227114. DOI: 10.1007/s40620-022-01482-y.

Regional Hypertonic Citrate Anticoagulation in Membrane Therapeutic Plasma Exchange: A Case Series.

Reis T, Ramos de Freitas G, Reis F, Cascelli de Azevedo M, Dias P, Figueiredo Santos D Can J Kidney Health Dis. 2021; 8:20543581211054736.

PMID: 34777842 PMC: 8579339. DOI: 10.1177/20543581211054736.

A Double Catheter Approach for Extracorporeal CO Removal Integrated Within a Continuous Renal Replacement Circuit.

De Bels D, Pierrakos C, Spapen H, Honore P J Transl Int Med. 2019; 6(4):157-158.

PMID: 30637200 PMC: 6326030. DOI: 10.2478/jtim-2018-0030.

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