Stem Cell Therapy in Autism: Recent Insights

Overview

Journal Stem Cells Cloning

Publisher Dove Medical Press

Specialty Biotechnology

Date 2018 Nov 15

PMID 30425534

Citations 18

Authors

Dario Siniscalco

Suresh Kannan

Neomar Semprun-Hernandez

Adrien A Eshraghi

Anna Lisa Brigida

Nicola Antonucci

Affiliations

Soon will be listed here.

Abstract

Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.

Citing Articles

Autologous cord blood individualized supplements in autistic spectrum disorder: CORDUS study results.

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Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway.

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Stem Cell Secretions as a Potential Therapeutic Agent for Autism Spectrum Disorder: A Narrative Review.

Darwish M, El Hajj R, Khayat L, Alaaeddine N Stem Cell Rev Rep. 2024; 20(5):1252-1272.

PMID: 38630359 DOI: 10.1007/s12015-024-10724-4.

Advances in the Treatment of Autism Spectrum Disorder: Current and Promising Strategies.

Yenkoyan K, Ounanian Z, Mirumyan M, Hayrapetyan L, Zakaryan N, Sahakyan R Curr Med Chem. 2023; 31(12):1485-1511.

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Haste Makes Waste: There Is No Solid Evidence to Translate the Use of Stem Cells into Clinical Practice for Children with Autism Spectrum Disorder.

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