Assessing Bone Mineral Changes in Response to Vitamin D Supplementation Using Natural Variability in Stable Isotopes of Calcium in Urine

Overview

Journal Sci Rep

Specialty Science

Date 2018 Nov 15

PMID 30425255

Citations 7

Authors

Ravi Rangarajan

Surajit Mondal

Prashanth Thankachan

Ramananda Chakrabarti

Anura V Kurpad

Affiliations

Soon will be listed here.

Abstract

Osteoporosis is a chronic disease of public health importance, particularly in low and middle income countries. Measuring the bone mineral balance (BMB) in a non-invasive manner, and its response to different interventions, is critical to the definition of optimal strategies for its prevention and management. In this study, we demonstrate the usefulness of natural variability in calcium isotopes (δCa) of urine and the derived BMB estimates as a biomarker of bone health and its responsiveness to interventions. Vitamin D is commonly used as a supplement for the prevention and treatment of osteoporosis, along with calcium supplements. We studied the effect of a short term vitamin D supplementation on changes in urine δCa and the derived BMB. δCa before and after the vitamin D supplementation yielded a statistically significant change (p = 0.050) with a positive δCa enrichment. The mean derived BMB was net positive (0.04 ± 0.05) in comparison to a net negative value for the control group (-0.03 ± 0.01). These results indicate the potential usefulness of urinary natural δCa and the derived BMB, which, along with bone mineral density could be used as a sensitive marker for precision in the prevention and treatment of osteoporosis.

Citing Articles

The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: protocol for a randomised controlled crossover trial.

Coombs C, Wardle S, Shroff R, Eisenhauer A, Tang J, Fraser W BMC Musculoskelet Disord. 2023; 24(1):496.

PMID: 37328859 PMC: 10273742. DOI: 10.1186/s12891-023-06600-w.

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs.

Voulgaridou G, Papadopoulou S, Detopoulou P, Tsoumana D, Giaginis C, Kondyli F Diseases. 2023; 11(1).

PMID: 36810543 PMC: 9944083. DOI: 10.3390/diseases11010029.

Nutraceutical prospects of against the infectious viruses.

Ghosh A, Ghosh B, Parihar N, Ilaweibaphyrnai M, Panda S, Alexander A Food Biosci. 2022; 50:101977.

PMID: 36059903 PMC: 9423882. DOI: 10.1016/j.fbio.2022.101977.

Calcium status assessment at the population level: Candidate approaches and challenges.

Rana Z, Bourassa M, Gomes F, Khadilkar A, Mandlik R, Owino V Ann N Y Acad Sci. 2022; 1517(1):93-106.

PMID: 36044378 DOI: 10.1111/nyas.14886.

Nutritional Calcium Supply Dependent Calcium Balance, Bone Calcification and Calcium Isotope Ratios in Rats.

Rott J, Toepfer E, Bartosova M, Kolevica A, Heuser A, Rabe M Int J Mol Sci. 2022; 23(14).

PMID: 35887143 PMC: 9322359. DOI: 10.3390/ijms23147796.

References

Gueguen L, Pointillart A . The bioavailability of dietary calcium. J Am Coll Nutr. 2000; 19(2 Suppl):119S-136S. DOI: 10.1080/07315724.2000.10718083. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Souberbielle J, Prie D, Courbebaisse M, Friedlander G, Houillier P, Maruani G . [Update on vitamin D and evaluation of vitamin D status]. Ann Endocrinol (Paris). 2008; 69(6):501-10. DOI: 10.1016/j.ando.2008.07.010. View

Tang O, Juraschek S, Appel L . Design Features of Randomized Clinical Trials of Vitamin D and Falls: A Systematic Review. Nutrients. 2018; 10(8). PMC: 6115709. DOI: 10.3390/nu10080964. View

Harvey N, Dennison E, Cooper C . Osteoporosis: impact on health and economics. Nat Rev Rheumatol. 2010; 6(2):99-105. DOI: 10.1038/nrrheum.2009.260. View

Dibba B, Prentice A, Ceesay M, Stirling D, Cole T, Poskitt E . Effect of calcium supplementation on bone mineral accretion in gambian children accustomed to a low-calcium diet. Am J Clin Nutr. 2000; 71(2):544-9. DOI: 10.1093/ajcn/71.2.544. View

Tang B, Eslick G, Nowson C, Smith C, Bensoussan A . Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007; 370(9588):657-66. DOI: 10.1016/S0140-6736(07)61342-7. View

Ma Y, Olendzki B, Pagoto S, Hurley T, Magner R, Ockene I . Number of 24-hour diet recalls needed to estimate energy intake. Ann Epidemiol. 2009; 19(8):553-9. PMC: 2803049. DOI: 10.1016/j.annepidem.2009.04.010. View

Watts N . Fundamentals and pitfalls of bone densitometry using dual-energy X-ray absorptiometry (DXA). Osteoporos Int. 2004; 15(11):847-54. DOI: 10.1007/s00198-004-1681-7. View

10.

Heuser A, Eisenhauer A . A pilot study on the use of natural calcium isotope (44Ca/40Ca) fractionation in urine as a proxy for the human body calcium balance. Bone. 2009; 46(4):889-96. DOI: 10.1016/j.bone.2009.11.037. View

11.

Morgan J, Skulan J, Gordon G, Romaniello S, Smith S, Anbar A . Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes. Proc Natl Acad Sci U S A. 2012; 109(25):9989-94. PMC: 3382538. DOI: 10.1073/pnas.1119587109. View

12.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

13.

Skulan J, Bullen T, Anbar A, Puzas J, Shackelford L, LeBlanc A . Natural calcium isotopic composition of urine as a marker of bone mineral balance. Clin Chem. 2007; 53(6):1155-8. DOI: 10.1373/clinchem.2006.080143. View

14.

Harvey N, Dennison E, Cooper C . Osteoporosis: a lifecourse approach. J Bone Miner Res. 2014; 29(9):1917-25. DOI: 10.1002/jbmr.2286. View

15.

Barragry J, France M, Corless D, Gupta S, Switala S, Boucher B . Intestinal cholecalciferol absorption in the elderly and in younger adults. Clin Sci Mol Med. 1978; 55(2):213-20. DOI: 10.1042/cs0550213. View

16.

Seibel M . Biochemical markers of bone metabolism in the assessment of osteoporosis: useful or not?. J Endocrinol Invest. 2003; 26(5):464-71. DOI: 10.1007/BF03345204. View

17.

. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994; 843:1-129. View

18.

Genant H, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J . Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int. 2000; 10(4):259-64. DOI: 10.1007/s001980050224. View

19.

Aloia J, Feuerman M, Yeh J . Reference range for serum parathyroid hormone. Endocr Pract. 2006; 12(2):137-44. PMC: 1482827. DOI: 10.4158/EP.12.2.137. View

20.

Channon M, Gordon G, Morgan J, Skulan J, Smith S, Anbar A . Using natural, stable calcium isotopes of human blood to detect and monitor changes in bone mineral balance. Bone. 2015; 77:69-74. DOI: 10.1016/j.bone.2015.04.023. View