Bioinspired Benzoxanthene Lignans As a New Class of Antimycotic Agents: Synthesis and Spp. Growth Inhibition

In this work we synthetized the bioinspired benzoxanthene lignans (BXLs) , , and the phenazine derivative as potential antimycotic agents. MICs and MFCs against strains were determined. In a preliminary screening, compounds , , , , were substantially inactive. Compounds and showed antifungal activity, being able to inhibit the growth of the majority of strains with MIC values in the range 4.6-19.2 µM () and 26.0-104.3 µM (); for three strains, the MICs were lower than those obtained using the antimycotic drug fluconazole. The three BXLs , and showed some MIC values lower than that of fluconazole; was also active against two non strains resistant to fluconazole. Phenazine , although active only against one strain (MIC = 1.3 µM), was one order of magnitude more potent than fluconazole. All the BXLs were fungicidal.