Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2018 Nov 14

PMID 30420966

Citations 5

Authors

Chenyang Zhao

Jinlan Gao

Sen Li

Qi Liu

Xiaoyu Hou

Shenghuan Liu

Xuesha Xing

Manni Sun

Shusen Wang

Yang Luo

Affiliations

Soon will be listed here.

Abstract

Recent data has shown that cyclin G2 () is an atypical cyclin that inhibits cell cycle progression and is often dysregulated in human cancers. The involvement of cyclin G2 in the occurrence and development of diabetic nephropathy (DN) has not been determined. In the present study, we conducted cyclin G2 knockout studies to determine whether this protein regulates glomerulosclerosis in DN mice. We found that cyclin G2 regulated the expression of renal glomerulosclerosis-related proteins via the canonical Wnt signalling pathway in glomerular mesangial cells. A cyclin G2 deficiency resulted in more severe renal injury in DN mice. These findings provided new insight into the pathogenesis of DN, revealing that cyclin G2 has a protective role in glomerulosclerosis and is a potential new target for the prevention and treatment of DN.

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Corrigendum to "Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling".

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References

Lin C, Wang J, Huang Y, Kuo Y, Surendran K, Wang F . Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol. 2006; 17(10):2812-20. DOI: 10.1681/ASN.2005121355. View

Mima A . Diabetic nephropathy: protective factors and a new therapeutic paradigm. J Diabetes Complications. 2013; 27(5):526-30. DOI: 10.1016/j.jdiacomp.2013.03.003. View

Wu X, Gao Y, Xu L, Dang W, Yan H, Zou D . Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytes. Sci Rep. 2017; 7(1):9371. PMC: 5571220. DOI: 10.1038/s41598-017-09907-6. View

Bennin D, Don A, Brake T, McKenzie J, Rosenbaum H, Ortiz L . Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem. 2002; 277(30):27449-67. DOI: 10.1074/jbc.M111693200. View

Zhou T, He X, Cheng R, Zhang B, Zhang R, Chen Y . Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2011; 55(1):255-66. DOI: 10.1007/s00125-011-2314-2. View

Kawakami T, Ren S, Duffield J . Wnt signalling in kidney diseases: dual roles in renal injury and repair. J Pathol. 2012; 229(2):221-31. DOI: 10.1002/path.4121. View

Sun Y, Su Y, Li J, Wang L . Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy. Biochem Biophys Res Commun. 2013; 433(4):359-61. DOI: 10.1016/j.bbrc.2013.02.120. View

Bock A, Leigh N, Bryda E . Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. In Vitro Cell Dev Biol Anim. 2014; 50(6):572-9. PMC: 4062835. DOI: 10.1007/s11626-014-9734-5. View

Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V . Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell Cycle. 2015; 14(14):2293-300. PMC: 4613656. DOI: 10.1080/15384101.2015.1046647. View

10.

Bernaudo S, Salem M, Qi X, Zhou W, Zhang C, Yang W . Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signalling. Oncogene. 2016; 35(36):4828. PMC: 5024151. DOI: 10.1038/onc.2016.65. View

11.

Kim Y, Shintani S, Kohno Y, Zhang R, Wong D . Cyclin G2 dysregulation in human oral cancer. Cancer Res. 2004; 64(24):8980-6. DOI: 10.1158/0008-5472.CAN-04-1926. View

12.

Lemley K, Elger M, Kretzler M, Nagata M, Sakai T, Uiker S . The glomerular mesangium: capillary support function and its failure under experimental conditions. Clin Investig. 1992; 70(9):843-56. DOI: 10.1007/BF00180755. View

13.

Xiao L, Wang M, Yang S, Liu F, Sun L . A glimpse of the pathogenetic mechanisms of Wnt/β-catenin signaling in diabetic nephropathy. Biomed Res Int. 2014; 2013:987064. PMC: 3886614. DOI: 10.1155/2013/987064. View

14.

Hu C, Sun L, Xiao L, Han Y, Fu X, Xiong X . Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy. Curr Med Chem. 2015; 22(24):2858-70. PMC: 4863711. DOI: 10.2174/0929867322666150625095407. View

15.

Guo Y, Xiao L, Sun L, Liu F . Wnt/beta-catenin signaling: a promising new target for fibrosis diseases. Physiol Res. 2012; 61(4):337-46. DOI: 10.33549/physiolres.932289. View

16.

Mader J, Resch Z, McLean G, Mikkelsen J, Oxvig C, Marler R . Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy. J Endocrinol. 2013; 219(1):51-8. PMC: 3820014. DOI: 10.1530/JOE-13-0167. View

17.

Dai C, Stolz D, Kiss L, Monga S, Holzman L, Liu Y . Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol. 2009; 20(9):1997-2008. PMC: 2736766. DOI: 10.1681/ASN.2009010019. View

18.

Mega C, Teixeira-de-Lemos E, Fernandes R, Reis F . Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes. J Diabetes Res. 2017; 2017:5164292. PMC: 5643039. DOI: 10.1155/2017/5164292. View

19.

Aguilar V, Annicotte J, Escote X, Vendrell J, Langin D, Fajas L . Cyclin G2 regulates adipogenesis through PPAR gamma coactivation. Endocrinology. 2010; 151(11):5247-54. PMC: 3000854. DOI: 10.1210/en.2010-0461. View

20.

Zimmermann M, Arachchige-Don A, Donaldson M, Dallapiazza R, Cowan C, Horne M . Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem. 2012; 287(27):22838-53. PMC: 3391138. DOI: 10.1074/jbc.M112.376855. View