GENETIC AND EPIGENETIC CAUSES OF OBESITY

Overview

Journal Adolesc Med State Art Rev

Specialty Pediatrics

Date 2018 Nov 13

PMID 30416642

Citations 89

Authors

Vidhu V Thaker

Affiliations

Soon will be listed here.

Abstract

Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics, metagenomics and the environment. With the increasing access to high precision diagnostic tools for genetic investigations, numerous genes influencing the phenotype have been identified, especially in early onset severe obesity. This review summarizes the current knowledge on the known genetic causes of obesity and the available therapeutic options. Furthermore, we discuss the role and potential mechanism of epigenetic changes that may be involved as mediators of the environmental influences and that may provide future opportunities for intervention.

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