The Biological Roles of Translation Initiation Factor 3b

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2018 Nov 13

PMID 30416377

Citations 8

Authors

Xuefei Feng

Juan Li

Peijun Liu

Affiliations

Soon will be listed here.

Abstract

Translation has important roles in almost all physiological and pathological processes, and translation initiation factors are particularly relevant to the translation initiation step, which is the most important step in translation regulation. Translation initiation factor 3b (eIF3b), a key subunit of the largest translation initiation factor 3 (eIF3), is widely considered a scaffold protein that acts to ensure the accuracy of translation initiation. A series of recent finds has revealed that eIF3 is closely related to oncogenesis. However, the concrete mechanism by which eIF3b is involve in carcinogenesis remains elusive. Here, we summarize a series of research findings regarding the relationship between eIF3b, translation and cancer.

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