Spliceosomal RNA U6 is Remarkably Conserved from Yeast to Mammals

Overview

Journal Nature

Specialty Science

Date 1988 Jul 21

PMID 3041282

Citations 200

Authors

D A Brow

C Guthrie

Affiliations

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Abstract

The small nuclear RNA U6 and its gene have been isolated from yeast. In striking contrast to other yeast spliceosomal RNAs, U6 is very similar in size, sequence and structure to its mammalian homologue. The single-copy gene is essential. These properties suggest a central role in pre-mRNA processing. An extensive base-pairing interaction with U4 snRNA is described; the destabilization of the U4/U6 complex seen during splicing thus requires a large conformational change.

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