Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

Overview

Journal Skin Appendage Disord

Specialty Dermatology

Date 2018 Nov 10

PMID 30410894

Citations 9

Authors

Lizeth Martinez-Jacobo

Claudia I Ancer-Arellano

Rocio Ortiz-Lopez

Mauricio Salinas-Santander

Cesar Daniel Villarreal-Villarreal

Jesus Ancer-Rodriguez

Bianka Camacho-Zamora

Viviana Zomosa-Signoret

Carlos E Medina-De la Garza

Jorge Ocampo-Candiani

Augusto Rojas-Martinez

Affiliations

Soon will be listed here.

Abstract

Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. and genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.

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The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia.

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