Review of Catheter-Associated Urinary Tract Infections and Urinary Tract Models

Overview

Journal J Healthc Eng

Specialty Biomedical Engineering

Date 2018 Nov 9

PMID 30405898

Citations 32

Authors

Yvonne J Cortese

Victoria E Wagner

Morgan Tierney

Declan Devine

Andrew Fogarty

Affiliations

Soon will be listed here.

Abstract

Catheter-associated urinary tract infections (CAUTIs) are one of the most common nosocomial infections and can lead to numerous medical complications from the mild catheter encrustation and bladder stones to the severe septicaemia, endotoxic shock, and pyelonephritis. Catheters are one of the most commonly used medical devices in the world and can be characterised as either indwelling (ID) or intermittent catheters (IC). The primary challenges in the use of IDs are biofilm formation and encrustation. ICs are increasingly seen as a solution to the complications caused by IDs as ICs pose no risk of biofilm formation due to their short time in the body and a lower risk of bladder stone formation. Research on IDs has focused on the use of antimicrobial and antibiofilm compounds, while research on ICs has focused on preventing bacteria entering the urinary tract or coming into contact with the catheter. There is an urgent need for urinary tract models to facilitate faster research and development for CAUTI prevention. There are currently three urinary tract models that test IDs; however, there is only a single very limited model for testing ICs. There is currently no standardised urinary tract model to test the efficacies of ICs.

Citing Articles

Oral ciprofloxacin biofilm activity in a catheter-associated urinary tract infection model.

Abbott I, Anderson C, van Gorp E, Wallis S, Roberts J, Meletiadis J J Antimicrob Chemother. 2024; 80(2):413-426.

PMID: 39626168 PMC: 11787899. DOI: 10.1093/jac/dkae424.

Microbiological profile and antibiotic susceptibility profile of urine cultures in patients with spinal cord injury-retrospective study.

Ferreira N, Branco R, Pimentel S, Paco M, Coelho I, Serpa L Porto Biomed J. 2024; 9(6):272.

PMID: 39544844 PMC: 11560116. DOI: 10.1097/j.pbj.0000000000000272.

New Antimicrobial Materials Based on Plasticized Polyvinyl Chloride for Urinary Catheters: Preparation and Testing.

Deleanu I, Grosu E, Ficai A, Ditu L, Motelica L, Oprea O Polymers (Basel). 2024; 16(21).

PMID: 39518238 PMC: 11548089. DOI: 10.3390/polym16213028.

Advances in experimental bladder models: bridging the gap between in vitro and in vivo approaches for investigating urinary tract infections.

Nissanka M, Dilhari A, Wijesinghe G, Weerasekera M BMC Urol. 2024; 24(1):206.

PMID: 39313789 PMC: 11418205. DOI: 10.1186/s12894-024-01590-w.

The Development of a Biomimetic Model of Bacteria Migration on Indwelling Urinary Catheter Surfaces.

Cortese Y, Fayne J, Colbert D, Devine D, Fogarty A Biomimetics (Basel). 2024; 9(8).

PMID: 39194470 PMC: 11353059. DOI: 10.3390/biomimetics9080491.

References

Townsley L, Shank E . Natural-Product Antibiotics: Cues for Modulating Bacterial Biofilm Formation. Trends Microbiol. 2017; 25(12):1016-1026. PMC: 5701842. DOI: 10.1016/j.tim.2017.06.003. View

Wang R, Neoh K, Kang E, Tambyah P, Chiong E . Antifouling coating with controllable and sustained silver release for long-term inhibition of infection and encrustation in urinary catheters. J Biomed Mater Res B Appl Biomater. 2014; 103(3):519-28. DOI: 10.1002/jbm.b.33230. View

Barford J, Anson K, Hu Y, Coates A . A model of catheter-associated urinary tract infection initiated by bacterial contamination of the catheter tip. BJU Int. 2008; 102(1):67-74. DOI: 10.1111/j.1464-410X.2008.07465.x. View

Trautner B, Darouiche R . Role of biofilm in catheter-associated urinary tract infection. Am J Infect Control. 2004; 32(3):177-83. PMC: 2963581. DOI: 10.1016/j.ajic.2003.08.005. View

Stickler D, Feneley R . The encrustation and blockage of long-term indwelling bladder catheters: a way forward in prevention and control. Spinal Cord. 2010; 48(11):784-90. DOI: 10.1038/sc.2010.32. View

Thomas R, Soumya K, Mathew J, Radhakrishnan E . Inhibitory effect of silver nanoparticle fabricated urinary catheter on colonization efficiency of Coagulase Negative Staphylococci. J Photochem Photobiol B. 2015; 149:68-77. DOI: 10.1016/j.jphotobiol.2015.04.034. View

Darouiche R, Donovan W, Del Terzo M, Thornby J, Rudy D, Hull R . Pilot trial of bacterial interference for preventing urinary tract infection. Urology. 2001; 58(3):339-44. DOI: 10.1016/s0090-4295(01)01271-7. View

Norsworthy A, Pearson M . From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis. Trends Microbiol. 2016; 25(4):304-315. PMC: 5365347. DOI: 10.1016/j.tim.2016.11.015. View

Coenye T, Nelis H . In vitro and in vivo model systems to study microbial biofilm formation. J Microbiol Methods. 2010; 83(2):89-105. DOI: 10.1016/j.mimet.2010.08.018. View

10.

Levering V, Cao C, Shivapooja P, Levinson H, Zhao X, Lopez G . Urinary catheter capable of repeated on-demand removal of infectious biofilms via active deformation. Biomaterials. 2015; 77:77-86. DOI: 10.1016/j.biomaterials.2015.10.070. View

11.

Chapple C . Overview on the lower urinary tract. Handb Exp Pharmacol. 2011; (202):1-14. DOI: 10.1007/978-3-642-16499-6_1. View

12.

Hooton T, Bradley S, Cardenas D, Colgan R, Geerlings S, Rice J . Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010; 50(5):625-63. DOI: 10.1086/650482. View

13.

Chakravarti A, Gangodawila S, Long M, Morris N, Blacklock A, Stickler D . An electrified catheter to resist encrustation by Proteus mirabilis biofilm. J Urol. 2005; 174(3):1129-32. DOI: 10.1097/01.ju.0000168618.79096.cb. View

14.

Gaonkar T, Sampath L, Modak S . Evaluation of the antimicrobial efficacy of urinary catheters impregnated with antiseptics in an in vitro urinary tract model. Infect Control Hosp Epidemiol. 2003; 24(7):506-13. DOI: 10.1086/502241. View

15.

Sherbondy A, Cooper C, Kalinowski S, Boyt M, Hawtrey C . Variability in catheter microwave sterilization techniques in a single clinic population. J Urol. 2002; 168(2):562-4. View

16.

Regev-Shoshani G, Ko M, Crowe A, Av-Gay Y . Comparative efficacy of commercially available and emerging antimicrobial urinary catheters against bacteriuria caused by E. coli in vitro. Urology. 2011; 78(2):334-9. DOI: 10.1016/j.urology.2011.02.063. View

17.

Stickler D . Clinical complications of urinary catheters caused by crystalline biofilms: something needs to be done. J Intern Med. 2014; 276(2):120-9. DOI: 10.1111/joim.12220. View

18.

Flores-Mireles A, Walker J, Caparon M, Hultgren S . Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015; 13(5):269-84. PMC: 4457377. DOI: 10.1038/nrmicro3432. View

19.

Stickler D . Bacterial biofilms in patients with indwelling urinary catheters. Nat Clin Pract Urol. 2008; 5(11):598-608. DOI: 10.1038/ncpuro1231. View

20.

Vapnek J, Maynard F, Kim J . A prospective randomized trial of the LoFric hydrophilic coated catheter versus conventional plastic catheter for clean intermittent catheterization. J Urol. 2003; 169(3):994-8. DOI: 10.1097/01.ju.0000051160.72187.e9. View