Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Nov 9

PMID 30405633

Citations 12

Authors

Kai Cao

David Marin

Takuye Sekine

Gabriela Rondon

Weicheng Zhao

Nathaniel T Smith

May Daher

Qing Wang

Li Li

Rima M Saliba

Ravi Pingali

Uday Popat

Chitra Hosing

Amanda Olson

Betul Oran

Rafet Basar

Rohtesh S Mehta

Richard Champlin

Elizabeth J Shpall

Katayoun Rezvani

Affiliations

Soon will be listed here.

Abstract

Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing have been shown to play a role in the immune surveillance of human CMV. We studied copy number in the donor graft and the risk of CMV reactivation after double umbilical cord blood transplantation (DUCBT) in 100 CMV seropositive DUCBT recipients and their corresponding cord blood (CB) grafts ( = 200). In the setting of DUCBT, the combined graft may contain 0-4 functional copies of gene. Sixteen patients received a combined graft with 1 or 2 copies and 84 patients were recipients of a combined graft with 3 or 4 copies. The 6-month cumulative incidence of CMV reactivation for the two groups was 93.7 and 58.4%, respectively ( = 0.0003). In multivariate analysis, low copies in the graft was an independent predictor of CMV reactivation (HR = 2.72, CI = 1.59-4.64; < 0.0001). Our study points to an important role for donor for protection against CMV reactivation after DUCBT. These novel findings may help identify patients at a higher risk of CMV reactivation after DUCBT. Donor genotype may be used as a potential criterion in the algorithm for graft selection for DUCBT.

Citing Articles

The Association of HLA-E Ligand and NKG2 Receptor Variation With Relapse and Mortality After Haploidentical Related Donor Transplantation.

Petersdorf E, McKallor C, Malkki M, Hsu K, He M, Spellman S Transplant Cell Ther. 2025; 31(3):137-156.

PMID: 39798802 PMC: 11875940. DOI: 10.1016/j.jtct.2025.01.004.

Genomic Markers Associated with Cytomegalovirus DNAemia in Kidney Transplant Recipients.

Shapira G, Volkov H, Fabian I, Mohr D, Bettinotti M, Shomron N Viruses. 2023; 15(11).

PMID: 38005904 PMC: 10674338. DOI: 10.3390/v15112227.

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.

Siemaszko J, Lacina P, Szymczak D, Szeremet A, Majcherek M, Czyz A Front Immunol. 2023; 14:1227897.

PMID: 37901227 PMC: 10611459. DOI: 10.3389/fimmu.2023.1227897.

Emergence of human CMV-induced NKG2C+ NK cells is associated with CD8+ T-cell recovery after allogeneic HCT.

van der Ploeg K, Sottile R, Kontopoulos T, Shaffer B, Papanicolaou G, Maloy M Blood Adv. 2023; 7(19):5784-5798.

PMID: 37196646 PMC: 10561005. DOI: 10.1182/bloodadvances.2022008952.

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications.

Siemaszko J, Marzec-Przyszlak A, Bogunia-Kubik K Arch Immunol Ther Exp (Warsz). 2023; 71(1):9.

PMID: 36899273 PMC: 10004456. DOI: 10.1007/s00005-023-00674-z.

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