The Rs878081 Polymorphism of AIRE Gene Increases the Risk of Rheumatoid Arthritis in a Chinese Han Population: a Case-control Study

Overview

Journal Braz J Med Biol Res

Specialties Biology
General Medicine

Date 2018 Nov 8

PMID 30403260

Citations 2

Authors

Haoyu Yang

Jin Li

Lifeng Jiang

Xijia Jiang

Xindie Zhou

Nanwei Xu

Affiliations

Soon will be listed here.

Abstract

The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic model analysis showed significant correlations between the TT genotype and the risk of RA (OR: 1.89, 95%CI: 1.03-3.47 in TT vs CC; OR: 1.84, 95%CI: 1.02-3.31 in TT vs CC+TC). Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased RA risk among non-smokers. In conclusion, rs878081 polymorphism of AIRE gene increases the risk of RA in a Chinese Han population.

Citing Articles

Genetic Polymorphisms in Exon 5 and Intron 5 and 7 of Are Associated with Rheumatoid Arthritis Risk in a Hungarian Population.

Berczi B, Nusser N, Peter I, Nemeth B, Kulisch A, Kiss Z Biology (Basel). 2024; 13(6).

PMID: 38927319 PMC: 11200628. DOI: 10.3390/biology13060439.

Association Between Polymorphisms rs870881(C>T), rs1003854(T>C) and Rheumatoid Arthritis Risk: A Hungarian Case-control Study.

Berczi B, Nusser N, Peter I, Nemeth B, Gyongyi Z In Vivo. 2024; 38(2):774-784.

PMID: 38418155 PMC: 10905445. DOI: 10.21873/invivo.13501.

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