The Relationship Between Phospholipids and Insulin Resistance: From Clinical to Experimental Studies

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Nov 8

PMID 30402908

Citations 54

Authors

Wenguang Chang

Grant M Hatch

Yu Wang

Fei Yu

Man Wang

Affiliations

Soon will be listed here.

Abstract

Insulin resistance induced by high-fat diet and impropriate life style is a major contributor to the pathogenesis of metabolic disease. However, the underlying molecular mechanisms remain unclear. Recent studies in metabolic dysfunction have extended this beyond simply elevated cholesterol and triglycerides levels and have identified a key role for lipid metabolism. For example, altered phospholipid metabolism has now become central in the pathogenesis of metabolic disease. In this review, we discuss the association between insulin sensitivity and phospholipid metabolism and highlight the most significant discoveries generated over the last several decades. Finally, we summarize the current knowledge surrounding the molecular mechanisms related to phospholipids and insulin resistance and provide new insight for future research into their relationship.

Citing Articles

Malignant Transformed and Non-Transformed Oral Leukoplakias Are Metabolically Different.

Martins-Chaves R, Bastos V, Vitorio J, Duarte-Andrade F, Pereira T, Leite-Lima F Int J Mol Sci. 2025; 26(5).

PMID: 40076430 PMC: 11898866. DOI: 10.3390/ijms26051802.

Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice.

Qian M, Jiang Z, Xu C, Wang L, Hu N Future Microbiol. 2024; 20(3):237-246.

PMID: 39711145 PMC: 11812427. DOI: 10.1080/17460913.2024.2444761.

Endurance Exercise Training Alters Lipidomic Profiles of Plasma and Eight Tissues in Rats: a MoTrPAC study.

Ortlund E, Hou Z, Chen C, Gaul D, Zhang T, Moore S Res Sq. 2024; .

PMID: 39606465 PMC: 11601870. DOI: 10.21203/rs.3.rs-5263273/v1.

Clinically relevant body composition phenotypes are associated with distinct circulating cytokine and metabolomic milieus in epithelial ovarian cancer patients.

Davis E, Hsiao H, Barone N, Rosario S, Cannioto R Front Immunol. 2024; 15:1419257.

PMID: 39575261 PMC: 11578747. DOI: 10.3389/fimmu.2024.1419257.

Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.

Wang C, Yang C, Western D, Ali M, Wang Y, Phuah C Nat Genet. 2024; 56(12):2685-2695.

PMID: 39528826 DOI: 10.1038/s41588-024-01973-7.

References

CLORE J, Harris P, Li J, Azzam A, Gill R, Zuelzer W . Changes in phosphatidylcholine fatty acid composition are associated with altered skeletal muscle insulin responsiveness in normal man. Metabolism. 2000; 49(2):232-8. DOI: 10.1016/s0026-0495(00)91455-0. View

Barber M, Risis S, Yang C, Meikle P, Staples M, Febbraio M . Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes. PLoS One. 2012; 7(7):e41456. PMC: 3405068. DOI: 10.1371/journal.pone.0041456. View

Li Z, Agellon L, Allen T, Umeda M, Jewell L, Mason A . The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 2006; 3(5):321-31. DOI: 10.1016/j.cmet.2006.03.007. View

Lesnefsky E, Chen Q, Tandler B, Hoppel C . Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies. Annu Rev Pharmacol Toxicol. 2016; 57:535-565. PMC: 11060135. DOI: 10.1146/annurev-pharmtox-010715-103335. View

Zeghari N, Vidal H, Younsi M, Ziegler O, Drouin P, Donner M . Adipocyte membrane phospholipids and PPAR-gamma expression in obese women: relationship to hyperinsulinemia. Am J Physiol Endocrinol Metab. 2000; 279(4):E736-43. DOI: 10.1152/ajpendo.2000.279.4.E736. View

Rhee E, Cheng S, Larson M, Walford G, Lewis G, McCabe E . Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011; 121(4):1402-11. PMC: 3069773. DOI: 10.1172/JCI44442. View

Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J . Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014; 103(2):137-49. DOI: 10.1016/j.diabres.2013.11.002. View

Kelley D, He J, Menshikova E, Ritov V . Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002; 51(10):2944-50. DOI: 10.2337/diabetes.51.10.2944. View

Newsom S, Brozinick J, Kiseljak-Vassiliades K, Strauss A, Bacon S, Kerege A . Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. J Appl Physiol (1985). 2016; 120(11):1355-63. PMC: 4891931. DOI: 10.1152/japplphysiol.00664.2015. View

10.

Wendel A, Lewin T, Coleman R . Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis. Biochim Biophys Acta. 2008; 1791(6):501-6. PMC: 2737689. DOI: 10.1016/j.bbalip.2008.10.010. View

11.

Siniossoglou S . Phospholipid metabolism and nuclear function: roles of the lipin family of phosphatidic acid phosphatases. Biochim Biophys Acta. 2012; 1831(3):575-81. DOI: 10.1016/j.bbalip.2012.09.014. View

12.

Younsi M, Quilliot D, Al-Makdissy N, Delbachian I, Drouin P, Donner M . Erythrocyte membrane phospholipid composition is related to hyperinsulinemia in obese nondiabetic women: effects of weight loss. Metabolism. 2002; 51(10):1261-8. DOI: 10.1053/meta.2002.35184. View

13.

Semba R, Gonzalez-Freire M, Moaddel R, Sun K, Fabbri E, Zhang P . Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults. J Clin Endocrinol Metab. 2018; 103(9):3331-3339. PMC: 6126893. DOI: 10.1210/jc.2018-00480. View

14.

Cao Y, Meng S, Chen Y, Feng J, Gu D, Yu B . MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature. 2017; 542(7641):372-376. PMC: 5319402. DOI: 10.1038/nature21077. View

15.

Claypool S, Koehler C . The complexity of cardiolipin in health and disease. Trends Biochem Sci. 2011; 37(1):32-41. PMC: 3259273. DOI: 10.1016/j.tibs.2011.09.003. View

16.

Toledo F, Menshikova E, Ritov V, Azuma K, Radikova Z, DeLany J . Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes. 2007; 56(8):2142-7. DOI: 10.2337/db07-0141. View

17.

Cheng M, Bhujwalla Z, Glunde K . Targeting Phospholipid Metabolism in Cancer. Front Oncol. 2017; 6:266. PMC: 5187387. DOI: 10.3389/fonc.2016.00266. View

18.

Filippi B, Abraham M, Silva P, Rasti M, LaPierre M, Bauer P . Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action. Cell Rep. 2017; 18(10):2301-2309. DOI: 10.1016/j.celrep.2017.02.035. View

19.

Benjamin D, Cravatt B, Nomura D . Global profiling strategies for mapping dysregulated metabolic pathways in cancer. Cell Metab. 2012; 16(5):565-77. PMC: 3539740. DOI: 10.1016/j.cmet.2012.09.013. View

20.

Borkman M, Storlien L, Pan D, Jenkins A, Chisholm D, Campbell L . The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med. 1993; 328(4):238-44. DOI: 10.1056/NEJM199301283280404. View