A Single-cell Survey of the Human First-trimester Placenta and Decidua

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2018 Nov 8

PMID 30402542

Citations 188

Authors

Hemant Suryawanshi

Pavel Morozov

Alexander Straus

Nicole Sahasrabudhe

Klaas E A Max

Aitor Garzia

Manjunath Kustagi

Thomas Tuschl

Zev Williams

Affiliations

Soon will be listed here.

Abstract

The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known and some subtypes previously unknown in placental villi and decidual context. Further detailed analysis revealed proliferating subpopulations, enrichment of cell type-specific transcription factors, and putative intercellular communication in the fetomaternal microenvironment. This study provides a blueprint to further the understanding of the roles of these cells in the placenta and decidua for maintenance of early gestation as well as pathogenesis in pregnancy-related disorders.

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