The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke

Overview

Journal Neurol Res Int

Publisher Wiley

Specialty Neurology

Date 2018 Nov 8

PMID 30402285

Citations 11

Authors

Emily R Rosario

Stephanie E Kaplan

Sepehr Khonsari

Garrett Vazquez

Niyant Solanki

Melanie Lane

Hiriam Brownell

Sheila S Rosenberg

Affiliations

Soon will be listed here.

Abstract

Background: While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits.

Objective: To investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke.

Methods: Using a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7). Each subject then received two 4-week periods of HBOT for a total of 40 90-minute treatments over a 12-week period. Subjects completed a battery of assessments and had blood drawn six times over the 9-month total duration of the study.

Results: We found improvements in cognition and executive function as well as physical abilities, specifically, improved gait. Participants reported improved sleep and quality of life following HBOT treatment. We also saw changes in serum levels of biomarkers for inflammation and neural recovery. In the functional domains where improvement was observed following HBOT treatment, the improvements were maintained up to 3 months following the last treatment. However, the physiological biomarkers showed a pattern of more transient changes following HBOT treatment.

Conclusions: Findings from this study support the idea of HBOT as a potential intervention following stroke.

Citing Articles

Hyperbaric Oxygen Therapy in Children with Brain Injury: A Retrospective Case Series.

Hajek M, Jor O, Tlapak J, Chmelar D Int J Med Sci. 2025; 22(3):473-481.

PMID: 39898239 PMC: 11783073. DOI: 10.7150/ijms.102884.

Hyperbaric oxygen therapy for poststroke insomnia: a systematic review and meta-analysis protocol.

Shi R, Meng W, Liu Z, Chang L, Lu R, Chen X BMJ Open. 2024; 14(3):e081642.

PMID: 38553058 PMC: 10982781. DOI: 10.1136/bmjopen-2023-081642.

Hyperbaric oxygen therapy for thalamic pain syndrome: case report.

Slade J, Kwan N, Lennox P, Gray R Front Neurol. 2024; 15:1364716.

PMID: 38545283 PMC: 10965551. DOI: 10.3389/fneur.2024.1364716.

Functional MRI evaluation of hyperbaric oxygen therapy effect on hand motor recovery in a chronic post-stroke patient: a case report and physiological discussion.

Catalogna M, Hadanny A, Parag Y, Adler M, Elkarif V, Efrati S Front Neurol. 2023; 14:1233841.

PMID: 37840920 PMC: 10570419. DOI: 10.3389/fneur.2023.1233841.

Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.

Gottfried I, Schottlender N, Ashery U Biomolecules. 2021; 11(10).

PMID: 34680155 PMC: 8533945. DOI: 10.3390/biom11101520.

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