Traditional Chinese Medicine Injections in the Treatment of Diabetic Foot: A Systematic Review and Meta-Analysis

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Nov 8

PMID 30402123

Citations 4

Authors

Lizi Tan

Qingyang Shi

Chunxiang Liu

Junhua Zhang

Hui Wang

Jingbo Zhai

Affiliations

Soon will be listed here.

Abstract

Context: The role of traditional Chinese medicine injections (TCMIs) in diabetic foot (DF) has not been well estimated.

Objective: To evaluate the clinical effective rate, safety, and the financial cost of TCMIs in treating DF and ulcer wound healing.

Methods: We searched PubMed, Embase, CENTRAL, China National Knowledge Infrastructure (CNKI), VIP database, and Wanfang database from inception to May 2018 to find all randomized control trials (RCTs) related to TCMIs in DF treatment. The search items were "Traditional Chinese Medicine Injection" AND "Diabetic foot or Diabetic foot ulcer" AND "random".

Study Selection And Synthesis: Only RCTs of TCMIs combined conventional therapies versus conventional therapies and that can be quantitatively synthesized were included. Finally, 17 studies and 1294 participants were included after extraction. Two investigators independently extracted and analyzed the data using RevMan5.3 software.

Results: The overall clinical effective rate of TCMI groups is higher than that of control groups [RR=1.27, 95CI % (1.20, 1.34), P<0.00001] based on fixed effect model analysis. Regarding motor nerve conduction velocity of median nerve and peroneal nerve, TCMI group showed a significant improvement (MD=3.84[2.28, 5.41], P<0.00001; MD=2.89[0.63, 5.15], P=0.01). Regarding plasma viscosity TCMI group showed a statistically difference (MD=0.27[0.04, 0.49], P=0.02). In terms of blood viscosity at high shear rate, there was an improvement of TCMI group (MD=0.36[0.05, 0.67], P=0.02). However, sensory nerve conduction velocity of peroneal nerve and median nerve showed a contradiction to motor nerve conduction velocity, respectively (MD=2.59[-1.69, 6.87], p=0.24; MD=2.73[-0.96, 6.43], P=0.15).

Conclusion: The data of this study shows that TCMIs can bring benefits to patients with diabetic foot. However, due to low methodological quality of included RCTs, more rigorous designed RCTs with large sample size are recommended to provide more high-quality evidence.

Citing Articles

Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta-analysis of randomized controlled trials.

Zamanifard M, Nasiri M, Yarahmadi F, Zonoori S, Razani O, Salajegheh Z Int Wound J. 2024; 21(2):e14760.

PMID: 38356150 PMC: 10867296. DOI: 10.1111/iwj.14760.

Development of a core outcome set in the clinical trials of traditional Chinese medicine for diabetic foot: A study protocol.

Dai X, Zi M, Liu C, Wang Y, Gao R Front Med (Lausanne). 2022; 9:1025833.

PMID: 36438030 PMC: 9682122. DOI: 10.3389/fmed.2022.1025833.

Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot.

Liu F, Li Y, Guo X, Liu R, Zhang H, Li Z World J Diabetes. 2022; 13(10):851-860.

PMID: 36312004 PMC: 9606791. DOI: 10.4239/wjd.v13.i10.851.

More studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot.

Ye Y, Yan Z, He L, Li C World J Diabetes. 2022; 13(7):581-583.

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