Cardiovascular and Metabolic Comorbidities in Rheumatoid Arthritis

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2018 Nov 7

PMID 30397830

Citations 20

Authors

Silvio Romano

Elisa Salustri

Piero Ruscitti

Francesco Carubbi

Maria Penco

Roberto Giacomelli

Affiliations

Soon will be listed here.

Abstract

Purpose Of The Review: An increased prevalence of cardiovascular risk factors in rheumatoid arthritis (RA) is reported. The absolute cardiovascular risk in RA patients is higher than in the general population, and although the RA prognosis has gradually improved, premature cardiovascular (CV) mortality remains a matter of fact. The purpose of this review is to shed light on CV and metabolic involvement in RA, with the aim of defining its best management.

Recent Findings: Multiple lines of evidence have revealed common mechanisms behind inflammatory and CV diseases and clarified the metabolic and CV pathways involved in RA and the effects of different pharmacological treatments. CV risk assessment should be mandatory in all RA patients, taking into account the impact of both diseases on patient's prognosis. Therefore, a multidisciplinary approach is the best management, and rheumatologists, cardiologists, and general practitioners must work together to significantly improve outcome and quality of life in RA patients. Future research could investigate the potential beneficial effects of a more aggressive pharmacological treatment of CV and metabolic risk factors.

Citing Articles

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Metabolic Abnormalities, Cardiovascular Disease, and Metabolic Syndrome in Adult Rheumatoid Arthritis Patients: Current Perspectives and Clinical Implications.

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A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Rheumatoid Arthritis (MEDRA): Study protocol.

Raad T, George E, Griffin A, Larkin L, Fraser A, Kennedy N Contemp Clin Trials Commun. 2022; 28:100919.

PMID: 35620325 PMC: 9126839. DOI: 10.1016/j.conctc.2022.100919.

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