Cancer and Comorbidity: The Role of Leptin in Breast Cancer and Associated Pathologies

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2018 Nov 7

PMID 30397604

Citations 8

Authors

Amitabha Ray

Affiliations

Soon will be listed here.

Abstract

Obesity is an important risk factor for postmenopausal breast cancer and also a poor prognostic factor among cancer patients. Moreover, obesity is associated with a number of health disorders such as insulin resistance/type-2 diabetes mellitus, hypertension, and other cardiovascular diseases. Frequently, these health disorders exhibit as components/complications of the metabolic syndrome. Nevertheless, obesity-related diseases may coexist with postmenopausal breast cancer; and these comorbid conditions could be substantial. Therefore, it may be assumed that different diseases including breast cancer could originate from a common pathological background in excessive adipose tissue. Adipocyte-released hormone-like cytokine (or adipokine) leptin behaves differently in a normal healthy state and obesity. A growing body of evidence suggests an important role of leptin in our major obesity-related health issues such as insulin resistance, hypertension, and neoplasia. In this context, this review describes the relationships of the abovementioned pathologies with leptin.

Citing Articles

Infections and immunity: associations with obesity and related metabolic disorders.

Ray A, Bonorden M, Pandit R, Nkhata K, Bishayee A J Pathol Transl Med. 2023; 57(1):28-42.

PMID: 36647284 PMC: 9846011. DOI: 10.4132/jptm.2022.11.14.

Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ.

Dana N, Ferns G, Nedaeinia R, Javanmard S Clin Transl Oncol. 2022; 25(3):601-610.

PMID: 36348225 DOI: 10.1007/s12094-022-02988-4.

Obesity Has a Systemic Effect on Immune Cells in Naïve and Cancer-Bearing Mice.

Neumann S, Campbell K, Woodall M, Evans M, Clarkson A, Young S Int J Mol Sci. 2021; 22(16).

PMID: 34445503 PMC: 8395769. DOI: 10.3390/ijms22168803.

Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer.

Boron D, Nowakowski R, Grabarek B, Zmarzly N, Oplawski M J Clin Med. 2021; 10(13).

PMID: 34202922 PMC: 8268664. DOI: 10.3390/jcm10132787.

Impact of Adjuvant Treatment on Heparanase Concentration in Invasive, Unilateral Breast Cancer Patients: Results of a Prospective Single-Centre Cohort Study.

Ruszkowska-Ciastek B, Bielawski K, Zarychta E, Rhone P J Clin Med. 2021; 10(10).

PMID: 34070058 PMC: 8158114. DOI: 10.3390/jcm10102184.

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