Polymorphisms in Enterovirus 71 Receptors Associated with Susceptibility and Clinical Severity

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Nov 6

PMID 30395634

Citations 9

Authors

Ting-Yu Yen

Wei-Liang Shih

Yi-Chuan Huang

Jian-Te Lee

Li-Min Huang

Luan-Yin Chang

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2).

Methods: We enrolled laboratory-confirmed EV71 cases and healthy age- and gender-matched controls in Taiwan from 2000 to 2012. We detected genetic polymorphisms in SCARB2, PSGL-1, and ANXA2 and correlated the results with EV71 susceptibility and severity.

Results: We collected 599 EV71 cases and 98 controls. Among EV71 patients, the male to female ratio was 1.61, and the mean age was 2.99±2.47 years. For clinical severity, 117 (19.6%) had severe central nervous system involvement with or without cardiopulmonary failure. For outcomes, 46 (7.7%) had sequelae, and 14 (2.3%) died. SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). PSGL-1 polymorphisms (rs7137098 and rs8179137) were significantly associated with severe EV71 infection (OR 1.46, 95% CI 1.1-1.96; and OR 1.47, 95% CI 1.07-2.03, respectively).

Conclusions: SCARB2 polymorphisms (rs6824953 and rs11097262) might be associated with EV71 susceptibility. PSGL-1 polymorphisms (rs7137098 and rs8179137) were associated with severe EV71 infection.

Citing Articles

Whole exome sequencing identifies genetic markers of enterovirus susceptibility in East Asians.

Sung C, Luxton G, Hung K, Wu Y, Wang C, Hsu C Front Microbiol. 2024; 15:1452595.

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Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection.

Wang X, Qian J, Mi Y, Li Y, Cao Y, Qiao K Virol J. 2024; 21(1):187.

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The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.

Duan F, Du Z, Wang Y, Luo L, Du L, Jiang H Biomol Biomed. 2023; 23(5):815-824.

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References

Wang S, Lei H, Huang K, Wu J, Wang J, Yu C . Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis. 2003; 188(4):564-70. DOI: 10.1086/376998. View

Chang L, Lin T, Hsu K, Huang Y, Lin K, Hsueh C . Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet. 1999; 354(9191):1682-6. DOI: 10.1016/S0140-6736(99)04434-7. View

Wang S, Liu C . Enterovirus 71: epidemiology, pathogenesis and management. Expert Rev Anti Infect Ther. 2009; 7(6):735-42. DOI: 10.1586/eri.09.45. View

Yamayoshi S, Yamashita Y, Li J, Hanagata N, Minowa T, Takemura T . Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat Med. 2009; 15(7):798-801. DOI: 10.1038/nm.1992. View

Lee M, Lin T, Chiang P, Li W, Luo S, Tsao K . An investigation of epidemic enterovirus 71 infection in Taiwan, 2008: clinical, virologic, and serologic features. Pediatr Infect Dis J. 2010; 29(11):1030-4. DOI: 10.1097/INF.0b013e3181e52945. View

Somers W, Tang J, Shaw G, Camphausen R . Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. 2000; 103(3):467-79. DOI: 10.1016/s0092-8674(00)00138-0. View

Fujita H, Takata Y, Kono A, Tanaka Y, Takahashi T, Himeno M . Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells. Biochem Biophys Res Commun. 1992; 184(2):604-11. DOI: 10.1016/0006-291x(92)90632-u. View

Knight J, Udalova I, Hill A, Greenwood B, Peshu N, Marsh K . A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet. 1999; 22(2):145-50. DOI: 10.1038/9649. View

Chen K, Chang H, Wang S, Cheng Y, Yang J . Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics. 2007; 120(2):e244-52. DOI: 10.1542/peds.2006-3331. View

10.

Chang L, Tsao K, Hsia S, Shih S, Huang C, Chan W . Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA. 2004; 291(2):222-7. DOI: 10.1001/jama.291.2.222. View

11.

Lv T, Li J, Han Z, Chen Z . Association of interleukin-17F gene polymorphism with enterovirus 71 encephalitis in patients with hand, foot, and mouth disease. Inflammation. 2013; 36(4):977-81. DOI: 10.1007/s10753-013-9629-8. View

12.

Chang L, Chang I, Chen W, Huang Y, Chen G, Shih S . HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008; 122(6):1271-6. DOI: 10.1542/peds.2007-3735. View

13.

Yamayoshi S, Ohka S, Fujii K, Koike S . Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71. J Virol. 2013; 87(6):3335-47. PMC: 3592140. DOI: 10.1128/JVI.02070-12. View

14.

Zhang X, Xu H, Chen X, Li X, Wang X, Ding S . Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection. Hum Genet. 2013; 133(2):187-97. PMC: 7088390. DOI: 10.1007/s00439-013-1367-3. View

15.

Cai Y, Chen Q, Zhou W, Chu C, Ji W, Ding Y . Association analysis of polymorphisms in OAS1 with susceptibility and severity of hand, foot and mouth disease. Int J Immunogenet. 2014; 41(5):384-92. DOI: 10.1111/iji.12134. View

16.

Yang J, Zhao N, Su N, Sun J, Lv T, Chen Z . Association of interleukin 10 and interferon gamma gene polymorphisms with enterovirus 71 encephalitis in patients with hand, foot and mouth disease. Scand J Infect Dis. 2012; 44(6):465-9. DOI: 10.3109/00365548.2011.649490. View

17.

Yang S, Chou Y, Wu C, Ho M . Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity. J Virol. 2011; 85(22):11809-20. PMC: 3209289. DOI: 10.1128/JVI.00297-11. View

18.

Laszik Z, Jansen P, Cummings R, Tedder T, McEver R, Moore K . P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Blood. 1996; 88(8):3010-21. View

19.

Nishimura Y, Shimojima M, Tano Y, Miyamura T, Wakita T, Shimizu H . Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. Nat Med. 2009; 15(7):794-7. DOI: 10.1038/nm.1961. View

20.

Cabrera M, Shaw M, Sharples C, Williams H, Castes M, Convit J . Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J Exp Med. 1995; 182(5):1259-64. PMC: 2192198. DOI: 10.1084/jem.182.5.1259. View