Nanoparticulate Matter Exposure Results in Neuroinflammatory Changes in the Corpus Callosum

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Nov 6

PMID 30395590

Citations 22

Authors

Robin Babadjouni

Arati Patel

Qinghai Liu

Kristina Shkirkova

Krista Lamorie-Foote

Michelle Connor

Drew M Hodis

Hank Cheng

Constantinos Sioutas

Todd E Morgan

Caleb E Finch

William J Mack

Affiliations

Soon will be listed here.

Abstract

Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.

Citing Articles

Air pollution: a latent key driving force of dementia.

Mohammadzadeh M, Khoshakhlagh A, Grafman J BMC Public Health. 2024; 24(1):2370.

PMID: 39223534 PMC: 11367863. DOI: 10.1186/s12889-024-19918-4.

Erratum: "Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model".

Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R Environ Health Perspect. 2024; 132(2):29001.

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Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity.

Zhang H, DAgostino C, Tulisiak C, Thorwald M, Bergkvist L, Lindquist A Heliyon. 2023; 9(4):e15622.

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Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice.

Lamorie-Foote K, Liu Q, Shkirkova K, Ge B, He S, Morgan T J Neurosci Res. 2022; 101(3):384-402.

PMID: 36464774 PMC: 10107949. DOI: 10.1002/jnr.25153.

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