Brain Opioids and Autism: an Updated Analysis of Possible Linkages

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 1987 Jun 1

PMID 3038836

Citations 26

Authors

T L Sahley

J Panksepp

Affiliations

Soon will be listed here.

Abstract

Considerable clinical evidence suggests that autistic children lack the normal ability or desire to engage others socially, as indicated by their poor social skills and inappropriate use of language for communicative purposes. Specifically, these children seem to lack normal amounts of social-emotional interest in other people, leading perhaps to a decreased initiative to communicate. This paper summarizes experimental evidence supporting a neurological theory, which posits that autism, at least partially, represents in the brain, such as brain opioids. These substances modulate social-emotional processes, and the possibility that blockade of opioid activity in the brain may be therapeutic for early childhood autism is discussed.

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References

Watson S, Berger P, Akil H, Mills M, Barchas J . Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects. Science. 1978; 201(4350):73-6. DOI: 10.1126/science.351804. View

HUTT C, Hutt S, Lee D, OUNSTED C . AROUSAL AND CHILDHOOD AUTISM. Nature. 1964; 204:908-9. DOI: 10.1038/204908a0. View

Zagon I, McLaughlin P . Naltrexone modulates body and brain development in rats: a role for endogenous opioid systems in growth. Life Sci. 1984; 35(20):2057-64. DOI: 10.1016/0024-3205(84)90563-0. View

Student M, Sohmer H . Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits. J Autism Child Schizophr. 1978; 8(1):13-20. DOI: 10.1007/BF01550274. View

Ritvo E, Freeman B, Geller E, Yuwiler A . Effects of fenfluramine on 14 outpatients with the syndrome of autism. J Am Acad Child Psychiatry. 1983; 22(6):549-58. DOI: 10.1097/00004583-198311000-00006. View

Najam N, Panksepp J . Effect of chronic neonatal morphine and naloxone on sensorimotor and social development of young rats. Pharmacol Biochem Behav. 1989; 33(3):539-44. DOI: 10.1016/0091-3057(89)90383-3. View

Plonsky M, Freeman P . The effects of methadone on the social behavior and activity of the rat. Pharmacol Biochem Behav. 1982; 16(4):569-71. DOI: 10.1016/0091-3057(82)90417-8. View

Curcio F . Sensorimotor functioning and communication in mute autistic children. J Autism Child Schizophr. 1978; 8(3):281-92. DOI: 10.1007/BF01539631. View

. Opioids in mental illness: theories, clinical observations, and treatment possibilities. Ann N Y Acad Sci. 1982; 398:1-512. View

10.

August G, Raz N, Baird T . Effects of fenfluramine on behavioral, cognitive, and affective disturbances in autistic children. J Autism Dev Disord. 1985; 15(1):97-107. DOI: 10.1007/BF01837901. View

11.

Barron J, Sandman C . Relationship of sedative-hypnotic response to self-injurious behavior and stereotypy by mentally retarded clients. Am J Ment Defic. 1983; 88(2):177-86. View

12.

Wardlaw S, Stark R, Daniel S, FRANTZ A . Effects of hypoxia on beta-endorphin and beta-lipotropin release in fetal, newborn, and maternal sheep. Endocrinology. 1981; 108(5):1710-5. DOI: 10.1210/endo-108-5-1710. View

13.

Simon N . Echolalic speech in childhood autism. Consideration of possible underlying loci of brain damage. Arch Gen Psychiatry. 1975; 32(11):1439-46. DOI: 10.1001/archpsyc.1975.01760290107013. View

14.

Blackstock E . Cerebral asymmetry and the development of early infantile autism. J Autism Child Schizophr. 1978; 8(3):339-53. DOI: 10.1007/BF01539636. View

15.

Levin E, Sharp B, Carlson H . Studies of naloxone-induced secretion of beta-endorphin immunoreactivity in dogs. Life Sci. 1984; 35(15):1535-45. DOI: 10.1016/0024-3205(84)90351-5. View

16.

Dewey M, Everard M . Autism, early infantile. Parents speak. J Autism Child Schizophr. 1974; 4(4):347-56. DOI: 10.1007/BF02105378. View

17.

CHERNICK V, Craig R . Naloxone reverses neonatal depression caused by fetal asphyxia. Science. 1982; 216(4551):1252-3. DOI: 10.1126/science.7200636. View

18.

Sandman C, Kastin A . The influence of fragments of the LPH chains on learning, memory and attention in animals and man. Pharmacol Ther. 1981; 13(1):39-60. DOI: 10.1016/0163-7258(81)90066-8. View

19.

Hauser S, Delong G, ROSMAN N . Pneumographic findings in the infantile autism syndrome. A correlation with temporal lobe disease. Brain. 1975; 98(4):667-88. DOI: 10.1093/brain/98.4.667. View

20.

Weizman R, Weizman A, Tyano S, Szekely G, Weissman B, Sarne Y . Humoral-endorphin blood levels in autistic, schizophrenic and healthy subjects. Psychopharmacology (Berl). 1984; 82(4):368-70. DOI: 10.1007/BF00427687. View