Effects of a Phagocytosis-stimulating Factor Derived from Polymorphonuclear Neutrophils on the Functions of Macrophages

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1987 Aug 1

PMID 3038750

Citations 1

Authors

Y Ishibashi

T Yamashita

Affiliations

Soon will be listed here.

Abstract

The effects of phagocytosis-stimulating factor (PSF) derived from polymorphonuclear neutrophils on macrophage functions were studied. PSF enhanced the initial rate of phagocytosis of serum-opsonized zymosan particles by macrophages, whereas it did not affect the phagocytosis of immunoglobulin G-sensitized and inert zymosan particles. Kinetic studies showed that PSF accelerated the ingestion step, but not the attachment step, of phagocytosis by macrophages. On the other hand, PSF did not affect the other macrophage functions such as O2- generation, chemotaxis, adherence, and enzyme release. These results suggest that PSF may specifically modulate the complement receptor function of macrophages. Immunoblot assay showed the absence of components in macrophage which reacted with purified antibodies against polymorphonuclear neutrophil-derived PSF, and an extract from phagocytosing macrophages had no phagocytosis-stimulating activity, indicating that the macrophages did not produce PSF-like substances.

Citing Articles

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PMID: 2759686 DOI: 10.1007/BF00914927.

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