Age is the Main Factor Related to Expiratory Flow Limitation During Constant Load Exercise

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2018 Nov 1

PMID 30379226

Authors

Patricia Rehder-Santos

Vinicius Minatel

Bruno Araujo Ribeiro

Richard Ducatti

Silvia Cristina Garcia de Moura-Tonello

Meliza Goi Roscani

Michel da Silva Reis

Ester Silva

Aparecida Maria Catai

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to investigate the interaction among the determinants of expiratory flow limitation (EFL), peak oxygen uptake (VO2peak), dysanapsis ratio (DR) and age during cycling at different intensities in young and middle-aged men.

Methods: Twenty-two (11 young and 11 middle-aged) men were assessed. Pulmonary function tests (DR), cardiopulmonary exercise tests (VO2peak) and two constant load tests (CLTs) at 75% (moderate intensity) and 125% (high intensity) of the gas exchange threshold were performed to assess EFL. EFL was classified using the percentage of EFL determined from both CLTs (mild: 5%-30%, moderate: 30%-50%, severe: >50%).

Results: Only the middle-aged group displayed EFL at both exercise intensities (p<0.05). However, the number of participants with EFL and the percentage of EFL were only associated with age during high-intensity exercise.

Conclusions: There was no interaction between the determinants. However, age was the only factor that was related to the presence of EFL during exercise in the age groups studied.

References

Stamford B . Exercise and the elderly. Exerc Sport Sci Rev. 1988; 16:341-79. View

Johnson B, Reddan W, Pegelow D, Seow K, Dempsey J . Flow limitation and regulation of functional residual capacity during exercise in a physically active aging population. Am Rev Respir Dis. 1991; 143(5 Pt 1):960-7. DOI: 10.1164/ajrccm/143.5_Pt_1.960. View

Catai A, Chacon-Mikahil M, Martinelli F, Forti V, Silva E, Golfetti R . Effects of aerobic exercise training on heart rate variability during wakefulness and sleep and cardiorespiratory responses of young and middle-aged healthy men. Braz J Med Biol Res. 2002; 35(6):741-52. DOI: 10.1590/s0100-879x2002000600016. View

Garber C, Blissmer B, Deschenes M, Franklin B, LaMonte M, Lee I . American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43(7):1334-59. DOI: 10.1249/MSS.0b013e318213fefb. View

Ofir D, Laveneziana P, Webb K, Lam Y, ODonnell D . Sex differences in the perceived intensity of breathlessness during exercise with advancing age. J Appl Physiol (1985). 2008; 104(6):1583-93. DOI: 10.1152/japplphysiol.00079.2008. View

Karsten M, Neves L, Neves V, Beltrame T, Borghi-Silva A, Arena R . Recent myocardial infarction patients present ventilatory limitation during aerobic exercise. Int J Cardiol. 2012; 161(3):180-1. DOI: 10.1016/j.ijcard.2012.06.026. View

. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002; 166(4):518-624. DOI: 10.1164/rccm.166.4.518. View

Babb T . Exercise ventilatory limitation: the role of expiratory flow limitation. Exerc Sport Sci Rev. 2012; 41(1):11-8. PMC: 3529766. DOI: 10.1097/JES.0b013e318267c0d2. View

Johnson B, Weisman I, Zeballos R, Beck K . Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop. Chest. 1999; 116(2):488-503. DOI: 10.1378/chest.116.2.488. View

10.

Higa M, Silva E, Neves V, Catai A, Gallo Jr L, Silva de Sa M . Comparison of anaerobic threshold determined by visual and mathematical methods in healthy women. Braz J Med Biol Res. 2007; 40(4):501-8. DOI: 10.1590/s0100-879x2007000400008. View

11.

Sheel A, Guenette J . Mechanics of breathing during exercise in men and women: sex versus body size differences?. Exerc Sport Sci Rev. 2008; 36(3):128-34. DOI: 10.1097/JES.0b013e31817be7f0. View

12.

Dominelli P, Guenette J, Wilkie S, Foster G, Sheel A . Determinants of expiratory flow limitation in healthy women during exercise. Med Sci Sports Exerc. 2011; 43(9):1666-74. DOI: 10.1249/MSS.0b013e318214679d. View

13.

Pellegrino R, Brusasco V, Rodarte J, Babb T . Expiratory flow limitation and regulation of end-expiratory lung volume during exercise. J Appl Physiol (1985). 1993; 74(5):2552-8. DOI: 10.1152/jappl.1993.74.5.2552. View

14.

Dominelli P, Foster G, Dominelli G, Henderson W, Koehle M, McKenzie D . Exercise-induced arterial hypoxaemia and the mechanics of breathing in healthy young women. J Physiol. 2013; 591(12):3017-34. PMC: 3832117. DOI: 10.1113/jphysiol.2013.252767. View

15.

Waterer G, Wan J, Kritchevsky S, Wunderink R, Satterfield S, Bauer D . Airflow limitation is underrecognized in well-functioning older people. J Am Geriatr Soc. 2001; 49(8):1032-8. DOI: 10.1046/j.1532-5415.2001.49205.x. View

16.

Neves L, Karsten M, Neves V, Beltrame T, Borghi-Silva A, Catai A . Relationship between inspiratory muscle capacity and peak exercise tolerance in patients post-myocardial infarction. Heart Lung. 2011; 41(2):137-45. DOI: 10.1016/j.hrtlng.2011.07.010. View

17.

Smith J, Rosenkranz S, Harms C . Dysanapsis ratio as a predictor for expiratory flow limitation. Respir Physiol Neurobiol. 2014; 198:25-31. DOI: 10.1016/j.resp.2014.04.001. View

18.

Miller M, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A . Standardisation of spirometry. Eur Respir J. 2005; 26(2):319-38. DOI: 10.1183/09031936.05.00034805. View

19.

Guenette J, Dominelli P, Reeve S, Durkin C, Eves N, Sheel A . Effect of thoracic gas compression and bronchodilation on the assessment of expiratory flow limitation during exercise in healthy humans. Respir Physiol Neurobiol. 2010; 170(3):279-86. DOI: 10.1016/j.resp.2010.01.017. View

20.

Derchak P, Stager J, Tanner D, Chapman R . Expiratory flow limitation confounds ventilatory response during exercise in athletes. Med Sci Sports Exerc. 2000; 32(11):1873-9. DOI: 10.1097/00005768-200011000-00009. View