The Effect of Latex on 7, 12-dimethylbenz () Anthracene-induced Breast Cancer in Rats

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2018 Nov 1

PMID 30377588

Citations 3

Authors

Fereshte Ghandehari

Mahnoosh Fatemi

Affiliations

Soon will be listed here.

Abstract

Objective: In traditional medicine, (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats.

Materials And Methods: Twenty-four female rats were randomly divided into 3 groups. In cancerous group, 0.5 ml 7, 12-dimethylbenz (a) anthracene was injected to nipple for breast cancer induction. The control group received sesame oil at the same volume through similar route. In fig latex treated group (Fle), breast cancer was induced and then 0.5 ml of fig latex was intratumorally injected on a daily basis for 4 weeks. Tumor size was measured at the 2, 4 and 6 weeks of the experiment. Blood samples were used for investigation of the hematological parameters and livers, kidneys and tumor tissues were removed for histopathological analysis.

Results: The tumor size in Fle group was significantly decreased compared to the cancerous group. Haematocrit, hemoglobin, RBC and their indices were significantly decreased, whereas platelet, leukocyte and white blood cell numbers were significantly increased in cancerous group compared to the control group. There were no changes in these parameters in the Fle group compared to the control group. There were severe pathological changes in the livers and kidneys of cancerous group, but not in Fle group.

Conclusion: These results suggest that fig latex could decrease tumor growth without having any adverse effect on hematological and histological factors. However, further investigation is required in this field.

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References

Wang J, Wang X, Jiang S, Lin P, Zhang J, Lu Y . Cytotoxicity of fig fruit latex against human cancer cells. Food Chem Toxicol. 2007; 46(3):1025-33. DOI: 10.1016/j.fct.2007.10.042. View

Abdelhalim M, Jarrar B . Histological alterations in the liver of rats induced by different gold nanoparticle sizes, doses and exposure duration. J Nanobiotechnology. 2012; 10:5. PMC: 3281779. DOI: 10.1186/1477-3155-10-5. View

Grimm Jr R, Neaton J, Ludwig W . Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortality. JAMA. 1985; 254(14):1932-7. View

Knight J . Review: Free radicals, antioxidants, and the immune system. Ann Clin Lab Sci. 2000; 30(2):145-58. View

Khodarahmi G, Ghasemi N, Hassanzadeh F, Safaie M . Cytotoxic Effects of Different Extracts and Latex of Ficus carica L. on HeLa cell Line. Iran J Pharm Res. 2013; 10(2):273-7. PMC: 3828905. View

Dolan L, Gelmon K, Courneya K, Mackey J, Segal R, Lane K . Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy. Cancer Epidemiol Biomarkers Prev. 2010; 19(11):2826-32. DOI: 10.1158/1055-9965.EPI-10-0521. View

Rowan A . Scientists and animal research: Dr. Jekyll or Mr. Hyde?. Soc Res (New York). 1995; 62(3):787-800. View

Eteraf-Oskouei T, Allahyari S, Akbarzadeh-Atashkhosrow A, Delazar A, Pashaii M, Gan S . Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evid Based Complement Alternat Med. 2015; 2015:760405. PMC: 4419259. DOI: 10.1155/2015/760405. View

Granger J, Kontoyiannis D . Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study. Cancer. 2009; 115(17):3919-23. DOI: 10.1002/cncr.24480. View

10.

Russo J, Russo I . Experimentally induced mammary tumors in rats. Breast Cancer Res Treat. 1996; 39(1):7-20. DOI: 10.1007/BF01806074. View

11.

Spell D, Jones Jr D, Harper W, David Bessman J . The value of a complete blood count in predicting cancer of the colon. Cancer Detect Prev. 2004; 28(1):37-42. DOI: 10.1016/j.cdp.2003.10.002. View

12.

Rickles F, Edwards R . Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood. 1983; 62(1):14-31. View

13.

Hashemi S, Abediankenari S, Ghasemi M, Azadbakht M, Yousefzadeh Y, Dehpour A . The Effect of Fig Tree Latex (Ficus carica) on Stomach Cancer Line. Iran Red Crescent Med J. 2012; 13(4):272-5. PMC: 3371962. View

14.

Lansky E, Paavilainen H, Pawlus A, Newman R . Ficus spp. (fig): ethnobotany and potential as anticancer and anti-inflammatory agents. J Ethnopharmacol. 2008; 119(2):195-213. DOI: 10.1016/j.jep.2008.06.025. View

15.

Sa G, Das T . Anti cancer effects of curcumin: cycle of life and death. Cell Div. 2008; 3:14. PMC: 2572158. DOI: 10.1186/1747-1028-3-14. View

16.

Liu C, Gong P, Yang J . [Relationship between circulating tumor cells and coagulation factors in primary lung cancer patients]. Zhonghua Zhong Liu Za Zhi. 2016; 38(5):368-71. DOI: 10.3760/cma.j.issn.0253-3766.2016.05.009. View

17.

Ay S, Eryilmaz M, Aksoy N, Okus A, Unlu Y, Sevinc B . Is early detection of colon cancer possible with red blood cell distribution width?. Asian Pac J Cancer Prev. 2015; 16(2):753-6. DOI: 10.7314/apjcp.2015.16.2.753. View

18.

Khan M, Blain J, Patterson J . Extracellular Proteases of Mucor pusillus. Appl Environ Microbiol. 1979; 37(4):719-24. PMC: 243287. DOI: 10.1128/aem.37.4.719-724.1979. View

19.

Jonkers J, Derksen P . Modeling metastatic breast cancer in mice. J Mammary Gland Biol Neoplasia. 2007; 12(2-3):191-203. DOI: 10.1007/s10911-007-9050-8. View

20.

Kanda M, Tanaka C, Kobayashi D, Mizuno A, Tanaka Y, Takami H . Proposal of the Coagulation Score as a Predictor for Short-Term and Long-Term Outcomes of Patients with Resectable Gastric Cancer. Ann Surg Oncol. 2016; 24(2):502-509. DOI: 10.1245/s10434-016-5544-1. View