How the Respiratory Epithelium Senses and Reacts to Influenza Virus

Overview

Journal Am J Respir Cell Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2018 Oct 30

PMID 30372120

Citations 14

Authors

Kambez H Benam

Laura Denney

Ling-Pei Ho

Affiliations

Soon will be listed here.

Abstract

The human lung is constantly exposed to the environment and potential pathogens. As the interface between host and environment, the respiratory epithelium has evolved sophisticated sensing mechanisms as part of its defense against pathogens. In this review, we examine how the respiratory epithelium senses and responds to influenza A virus, the biggest cause of respiratory viral deaths worldwide.

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References

Schmitz N, Kurrer M, Bachmann M, Kopf M . Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol. 2005; 79(10):6441-8. PMC: 1091664. DOI: 10.1128/JVI.79.10.6441-6448.2005. View

Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs M . A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection. PLoS Pathog. 2016; 12(1):e1005410. PMC: 4731390. DOI: 10.1371/journal.ppat.1005410. View

Kok W, Denney L, Benam K, Cole S, Clelland C, McMichael A . Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. J Leukoc Biol. 2011; 91(3):357-68. DOI: 10.1189/jlb.0411184. View

Zhang Y, Zhao Y, Li N, Peng Y, Giannoulatou E, Jin R . Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun. 2013; 4:1418. PMC: 3562464. DOI: 10.1038/ncomms2433. View

Manz B, Dornfeld D, Gotz V, Zell R, Zimmermann P, Haller O . Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. PLoS Pathog. 2013; 9(3):e1003279. PMC: 3610643. DOI: 10.1371/journal.ppat.1003279. View

Davidson S, Crotta S, McCabe T, Wack A . Pathogenic potential of interferon αβ in acute influenza infection. Nat Commun. 2014; 5:3864. PMC: 4033792. DOI: 10.1038/ncomms4864. View

Colina R, Costa-Mattioli M, Dowling R, Jaramillo M, Tai L, Breitbach C . Translational control of the innate immune response through IRF-7. Nature. 2008; 452(7185):323-8. DOI: 10.1038/nature06730. View

Prakash A, Smith E, Lee C, Levy D . Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J Biol Chem. 2005; 280(19):18651-7. PMC: 1167601. DOI: 10.1074/jbc.M501289200. View

Weber M, Sediri H, Felgenhauer U, Binzen I, Banfer S, Jacob R . Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I. Cell Host Microbe. 2015; 17(3):309-319. PMC: 4359673. DOI: 10.1016/j.chom.2015.01.005. View

10.

Xing Z, Harper R, Anunciacion J, Yang Z, Gao W, Qu B . Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol. 2010; 44(1):24-33. PMC: 3159084. DOI: 10.1165/rcmb.2009-0120OC. View

11.

Bosco A, Wiehler S, Proud D . Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection. BMC Genomics. 2016; 17:76. PMC: 4727386. DOI: 10.1186/s12864-016-2405-z. View

12.

Baron R, Choi A, Owen C, Choi A . Genetically manipulated mouse models of lung disease: potential and pitfalls. Am J Physiol Lung Cell Mol Physiol. 2011; 302(6):L485-97. PMC: 4074003. DOI: 10.1152/ajplung.00085.2011. View

13.

Meylan E, Tschopp J, Karin M . Intracellular pattern recognition receptors in the host response. Nature. 2006; 442(7098):39-44. DOI: 10.1038/nature04946. View

14.

Tran H, Lewis M, Tan L, Lester S, Baker L, Ng J . Immunolocalization of NLRP3 Inflammasome in Normal Murine Airway Epithelium and Changes following Induction of Ovalbumin-Induced Airway Inflammation. J Allergy (Cairo). 2012; 2012:819176. PMC: 3317233. DOI: 10.1155/2012/819176. View

15.

Kaplanski G . Interleukin-18: Biological properties and role in disease pathogenesis. Immunol Rev. 2017; 281(1):138-153. PMC: 7165732. DOI: 10.1111/imr.12616. View

16.

Perrone L, Plowden J, Garcia-Sastre A, Katz J, Tumpey T . H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog. 2008; 4(8):e1000115. PMC: 2483250. DOI: 10.1371/journal.ppat.1000115. View

17.

Neumann G, Noda T, Kawaoka Y . Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature. 2009; 459(7249):931-9. PMC: 2873852. DOI: 10.1038/nature08157. View

18.

Everitt A, Clare S, Pertel T, John S, Wash R, Smith S . IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012; 484(7395):519-23. PMC: 3648786. DOI: 10.1038/nature10921. View

19.

Sykes A, Edwards M, Macintyre J, Del Rosario A, Gielen V, Haas J . TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma. PLoS One. 2013; 8(6):e65921. PMC: 3688823. DOI: 10.1371/journal.pone.0065921. View

20.

Molinari N, Ortega-Sanchez I, Messonnier M, Thompson W, Wortley P, Weintraub E . The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007; 25(27):5086-96. DOI: 10.1016/j.vaccine.2007.03.046. View