Cellular Biology of Fracture Healing

Overview

Journal J Orthop Res

Publisher Wiley

Specialty Orthopedics

Date 2018 Oct 30

PMID 30370699

Citations 203

Authors

Chelsea S Bahney

Robert L Zondervan

Patrick Allison

Alekos Theologis

Jason W Ashley

Jaimo Ahn

Theodore Miclau

Ralph S Marcucio

Kurt D Hankenson

Affiliations

Soon will be listed here.

Abstract

The biology of bone healing is a rapidly developing science. Advances in transgenic and gene-targeted mice have enabled tissue and cell-specific investigations of skeletal regeneration. As an example, only recently has it been recognized that chondrocytes convert to osteoblasts during healing bone, and only several years prior, seminal publications reported definitively that the primary tissues contributing bone forming cells during regeneration were the periosteum and endosteum. While genetically modified animals offer incredible insights into the temporal and spatial importance of various gene products, the complexity and rapidity of healing-coupled with the heterogeneity of animal models-renders studies of regenerative biology challenging. Herein, cells that play a key role in bone healing will be reviewed and extracellular mediators regulating their behavior discussed. We will focus on recent studies that explore novel roles of inflammation in bone healing, and the origins and fates of various cells in the fracture environment. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Citing Articles

miR-138-5p inhibits healing of femoral fracture osteogenesis in rats by modulating osteoblast differentiation via SIRT1/FOXO1 axis.

Dai G, Jiang W, Feng B, Zhang L J Orthop Surg Res. 2025; 20(1):280.

PMID: 40082921 PMC: 11907804. DOI: 10.1186/s13018-025-05667-6.

mpECs with high Piezo2 expression promote fracture healing by driving angiogenesis through the Notch signaling pathway.

He L, Gong F, Wang J, Huang Y, Wang H BMC Musculoskelet Disord. 2025; 26(1):238.

PMID: 40069682 PMC: 11895173. DOI: 10.1186/s12891-025-08476-4.

CD47 is required for mesenchymal progenitor proliferation and fracture repair.

Zondervan R, Capobianco C, Jenkins D, Reicha J, Fredrick L, Lam C Bone Res. 2025; 13(1):29.

PMID: 40025005 PMC: 11873311. DOI: 10.1038/s41413-025-00409-0.

Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment.

Zhang S, Guo J, He Y, Su Z, Feng Y, Zhang L J Zhejiang Univ Sci B. 2025; 26(2):107-123.

PMID: 40015932 PMC: 11867785. DOI: 10.1631/jzus.B2300607.

Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration.

Weldon K, Longaker M, Ambrosi T Stem Cells. 2025; 43(3).

PMID: 39945760 PMC: 11892563. DOI: 10.1093/stmcls/sxaf006.

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