Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows

Overview

Journal J Vet Res

Publisher Sciendo

Specialty Veterinary Medicine

Date 2018 Oct 27

PMID 30364907

Citations 7

Authors

Alfredo Rosamel Rodriguez

Daniel Eduardo Herzberg

Marianne Patricia Werner

Heine Yacob Muller

Hedie Almagro Bustamante

Affiliations

Soon will be listed here.

Abstract

Introduction: Lameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS).

Material And Methods: A total of 100 Friesian and Jersey cows with lameness (parity range: 1-6; weight: 400-500 kg; milk yield: 22-28 L a day, and lactation stage less than 230 days) were selected. Animals were selected and grouped according to MS (MS 0-3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA.

Results: Cows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows.

Conclusion: Variations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows with lameness, but are insufficient to differentiate these states from the mildest pain states. Further studies are necessary in order to evaluate the potential use of these biomarkers in the detection of chronic bovine painful conditions.

Citing Articles

Pain pathophysiology and pharmacology of cattle: how improved understanding can enhance pain prevention, mitigation, and welfare.

Zoltick A, Mann S, Coetzee J Front Pain Res (Lausanne). 2024; 5:1396992.

PMID: 39258013 PMC: 11385012. DOI: 10.3389/fpain.2024.1396992.

Use of Infrared Thermography and Heart Rate Variability to Evaluate Autonomic Activity in Domestic Animals.

Ghezzi M, Ceriani M, Dominguez-Oliva A, Lendez P, Olmos-Hernandez A, Casas-Alvarado A Animals (Basel). 2024; 14(9).

PMID: 38731370 PMC: 11083326. DOI: 10.3390/ani14091366.

Evaluation of Substance P concentrations in the blood plasma of jugular and tail vein of healthy German Simmental cows.

Landinger A, Zablotski Y, Knubben-Schweizer G, Tschoner T BMC Vet Res. 2023; 19(1):218.

PMID: 37864162 PMC: 10588027. DOI: 10.1186/s12917-023-03768-0.

Changes in Dynamic Thiol/Disulfide Homeostasis, and Substance P, B-Endorphin and α-Tocopherol Concentrations in the Spinal Cord of Chronically Lame Dairy Cows.

Muller H, Herzberg D, Chihuailaf R, Strobel P, Werner M, Bustamante H Animals (Basel). 2023; 13(10).

PMID: 37238050 PMC: 10215632. DOI: 10.3390/ani13101620.

Substance P concentrations in the blood plasma and serum of adult cattle and calves during different painful procedures and conditions - a systematic review.

Tschoner T, Feist M BMC Vet Res. 2022; 18(1):232.

PMID: 35717202 PMC: 9206354. DOI: 10.1186/s12917-022-03304-6.

References

OConnor T, OConnell J, OBrien D, Goode T, Bredin C, Shanahan F . The role of substance P in inflammatory disease. J Cell Physiol. 2004; 201(2):167-80. DOI: 10.1002/jcp.20061. View

Ley S, Waterman A, Livingston A . Measurement of mechanical thresholds, plasma cortisol and catecholamines in control and lame cattle: a preliminary study. Res Vet Sci. 1996; 61(2):172-3. DOI: 10.1016/s0034-5288(96)90096-x. View

Ji R, Berta T, Nedergaard M . Glia and pain: is chronic pain a gliopathy?. Pain. 2013; 154 Suppl 1:S10-S28. PMC: 3858488. DOI: 10.1016/j.pain.2013.06.022. View

Coetzee J, Lubbers B, Toerber S, Gehring R, Thomson D, White B . Plasma concentrations of substance P and cortisol in beef calves after castration or simulated castration. Am J Vet Res. 2008; 69(6):751-62. DOI: 10.2460/ajvr.69.6.751. View

Allen K, Coetzee J, Edwards-Callaway L, Glynn H, Dockweiler J, KuKanich B . The effect of timing of oral meloxicam administration on physiological responses in calves after cautery dehorning with local anesthesia. J Dairy Sci. 2013; 96(8):5194-205. DOI: 10.3168/jds.2012-6251. View

Whay H, Main D, Green L, Webster A . Assessment of the welfare of dairy cattle using animal-based measurements: direct observations and investigation of farm records. Vet Rec. 2003; 153(7):197-202. DOI: 10.1136/vr.153.7.197. View

Martini L, Whistler J . The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol. 2007; 17(5):556-64. DOI: 10.1016/j.conb.2007.10.004. View

Chen W, McRoberts J, Marvizon J . μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience. 2014; 267:67-82. PMC: 3998911. DOI: 10.1016/j.neuroscience.2014.02.023. View

Whay H, Waterman A, Webster A, OBrien J . The influence of lesion type on the duration of hyperalgesia associated with hindlimb lameness in dairy cattle. Vet J. 1998; 156(1):23-9. DOI: 10.1016/s1090-0233(98)80058-0. View

10.

Tsigos C, Reed P, Weinkove C, White A, Young R . Plasma norepinephrine in sensory diabetic polyneuropathy. Diabetes Care. 1993; 16(5):722-7. DOI: 10.2337/diacare.16.5.722. View

11.

Lefcourt A, Elsasser T . Adrenal responses of Angus x Hereford cattle to the stress of weaning. J Anim Sci. 1995; 73(9):2669-76. DOI: 10.2527/1995.7392669x. View

12.

Coetzee J, Mosher R, KuKanich B, Gehring R, Robert B, Reinbold J . Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia. BMC Vet Res. 2012; 8:153. PMC: 3503738. DOI: 10.1186/1746-6148-8-153. View

13.

Hannibal K, Bishop M . Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2014; 94(12):1816-25. PMC: 4263906. DOI: 10.2522/ptj.20130597. View

14.

Bustamante H, Rodriguez A, Herzberg D, Werner M . Stress and pain response after oligofructose induced-lameness in dairy heifers. J Vet Sci. 2015; 16(4):405-11. PMC: 4701732. DOI: 10.4142/jvs.2015.16.4.405. View

15.

Reader J, Green M, Kaler J, Mason S, Green L . Effect of mobility score on milk yield and activity in dairy cattle. J Dairy Sci. 2011; 94(10):5045-52. DOI: 10.3168/jds.2011-4415. View

16.

Doehring A, Oertel B, Sittl R, Lotsch J . Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain. Pain. 2013; 154(1):15-23. DOI: 10.1016/j.pain.2012.06.011. View

17.

Borsook D, Becerra L, Hargreaves R . Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011; 11(58):197-207. View

18.

Osawa T, Nakao T, Moriyoshi M, Nakada K . Plasma beta-endorphin around parturition and its relationship to cortisol level and resumption of pituitary and ovarian functions in dairy cows. Anim Reprod Sci. 1998; 52(1):27-38. DOI: 10.1016/s0378-4320(98)00086-4. View

19.

Lay Jr D, Friend T, Bowers C, Grissom K, Jenkins O . A comparative physiological and behavioral study of freeze and hot-iron branding using dairy cows. J Anim Sci. 1992; 70(4):1121-5. DOI: 10.2527/1992.7041121x. View

20.

Shaw F, Tume R . Beta-endorphin and cortisol concentrations in plasma of cattle. Aust Vet J. 1990; 67(11):423-4. DOI: 10.1111/j.1751-0813.1990.tb03044.x. View