Lung Function Testing and Dopaminergic Medication in Parkinson's Disease Patients With and Without Dysphagia

Overview

Journal Mov Disord Clin Pract

Publisher Wiley

Specialty Neurology

Date 2018 Oct 27

PMID 30363501

Citations 2

Authors

Tareq Sawan

Mary Louise Harris

Christopher Kobylecki

Laura Baijens

Michel van Hooren

Emilia Michou

Affiliations

Soon will be listed here.

Abstract

Background: Swallowing function in individuals with Parkinson's disease (PD) can be negatively affected by dopaminergic medication with associated inhibition of brainstem reflexes. Three different "swallowing-safety" profiles of PD patients were previously observed, classified according to swallowing safety and levodopa.

Methods: Here, we investigated the effects of l-dopa on pulmonary function tests (PFTs) on 26 individuals with PD from the three different swallowing-safety profiles. PFTs results were compared to predicted values and direct comparisons between the groups with or without dysphagia were performed with nonparametric statistical tests (i.e., Kruskal-Wallis).

Results: A short (12-hour) withdrawal from l-dopa did not result in any significant changes in PFTs, and no differences on PFTs results were observed between the different dysphagic groups the and l-dopa state. No correlation was observed between the PFTs results with swallowing safety profiles of PD patients.

Conclusions: Although deglutition seems to be at least partially affected by dopaminergic repletion, dopaminergic mechanisms do not seem to be responsible for PD patients' performance in PFTs.

Citing Articles

Dysregulation of Respiratory Center Drive (P0.1) and Muscle Strength in Patients With Early Stage Idiopathic Parkinson's Disease.

Zhang W, Zhang L, Zhou N, Huang E, Li Q, Wang T Front Neurol. 2019; 10:724.

PMID: 31333573 PMC: 6618698. DOI: 10.3389/fneur.2019.00724.

Speech and Voice Response to a Levodopa Challenge in Late-Stage Parkinson's Disease.

Fabbri M, Guimaraes I, Cardoso R, Coelho M, Guedes L, Rosa M Front Neurol. 2017; 8:432.

PMID: 28878734 PMC: 5572389. DOI: 10.3389/fneur.2017.00432.

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