Association of Adiponectin and Rs1501299 of the Gene with Prediabetes in Jordan

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2018 Oct 27

PMID 30360393

Citations 9

Authors

Mahmoud A Alfaqih

Faheem Al-Mughales

Othman Al-Shboul

Mohammad Al Qudah

Yousef S Khader

Muhammad Al-Jarrah

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes mellitus (T2DM) is a worldwide health problem caused by resistance to insulin action. This chronic debilitating diseaseis preceded by a stage, known as prediabetes, in which a healthy lifestyle can delay the disease. The discovery of biochemical changes in prediabetes is important to identify individuals at risk of developing T2DM and in explaining disease pathogenesis. Adiponectin is secreted by fat cells and is linked with insulin resistance. Adiponectin levels are dysregulated in prediabetic subjects. This relationship had not been tested in Jordan. We recruited 130 subjects with prediabetes and 130 control subjects. We measured serum levels of adiponectin and genotyped subjects for three single nucleotide polymorphisms (SNPs) in the gene; rs266729, rs1501299 and rs2241766. In multivariate analysis, we found that serum adiponectin lowers the risk of prediabetes ( = 0.002; odds ratio (OR), 0.764; 95% confidence interval (CI), 0.646⁻0.905). The rs1501299 SNP of the gene was associated with prediabetes in our population ( = 0.041). Specifically, in multivariate analysis, the GT genotype of rs1501299 increased the risk of prediabetes ( = 0.010; OR, 2.350; 95% CI, 1.231⁻4.486) as well as the TT genotype ( = 0.006; OR, 4.774; 95% CI, 1.551⁻14.693). Our findings indicate that serum adiponectin and SNPs in the gene are associated with prediabetes in Jordan.

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