Intracarotid Infusion of ACNU and BCNU As Adjuvant Therapy of Malignant Gliomas. Clinical Aspects and Critical Considerations

Overview

Journal Acta Neurochir (Wien)

Specialty Neurosurgery

Date 1987 Jan 1

PMID 3035882

Citations 10

Authors

L Papavero

F LOEW

H Jaksche

Affiliations

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Abstract

Thirty patients with malignant gliomas were treated by operation, radiotherapy and additional intracarotid infusions of ACNU and BCNU. Positive results were obtained in the treatment of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multiforme were disappointing: neither survival time nor quality of life had been significantly improved. The protective effect of phenobarbitone against systemic toxicity by ACNU was not always confirmed in this study. Based on literature reports and our own experience the indications, technical aspects, unexpected complications and results of this therapeutic approach are discussed.

Citing Articles

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Therapy of glioblastoma multiforme: a cumulative experience of 10 years.

Obwegeser A, Ortler M, Seiwald M, Ulmer H, Kostron H Acta Neurochir (Wien). 1995; 137(1-2):29-33.

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Intra arterial chemotherapy with ACNU and radiotherapy in inoperable malignant gliomas.

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Cell death due to ACNU-induced DNA fragmentation: inhibition by cycloheximide.

Kobayashi T, Tominaga T, Yoshimoto T J Neurooncol. 1994; 22(1):23-31.

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