Research Progress on the Role and Mechanism of Action of Activin A in Brain Injury

Overview

Journal Front Neurosci

Date 2018 Oct 26

PMID 30356877

Citations 9

Authors

Xiaojuan Su

Lingyi Huang

Dongqiong Xiao

Yi Qu

Dezhi Mu

Affiliations

Soon will be listed here.

Abstract

Activin A belongs to the transforming growth factor superfamily and has a variety of biological functions. Studies have revealed that activin A can regulate the body's immune and inflammatory responses and participate in the regulation of cell death. In addition, activin A also has neurotrophic function and plays an important role in the repair of brain damage. This article summarizes recent advances in understanding the role and mechanism of action of activin A in brain injury and provides new hints into the application of activin A in the treatment of brain injury.

Citing Articles

The roles of pleiotrophin in brain injuries: a narrative review of the literature.

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Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues.

Wiens K, Wasti N, Ulloa O, Klegeris A Molecules. 2024; 29(23).

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Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis.

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Diminished vasculogenesis under inflammatory conditions is mediated by Activin A.

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Activin A alleviates neuronal injury through inhibiting cGAS-STING-mediated autophagy in mice with ischemic stroke.

Liu M, Li Y, Han S, Wang H, Li J J Cereb Blood Flow Metab. 2022; 43(5):736-748.

PMID: 36537048 PMC: 10108189. DOI: 10.1177/0271678X221147056.

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