The Effects of Stenting on Coronary Endothelium from a Molecular Biological View: Time for Improvement?

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Oct 25

PMID 30353645

Citations 35

Authors

Anne Cornelissen

Felix Jan Vogt

Affiliations

Soon will be listed here.

Abstract

Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of vascular endothelium. The damaged endothelium is intrinsically repaired by locally derived endothelial cells and by circulating endothelial progenitor cells from the blood, leading to re-population of the denuded regions within several weeks to months. However, the process of re-endothelialization is often incomplete or dysfunctional, promoting in-stent thrombosis and restenosis. The molecular and biomechanical mechanisms that influence the process of re-endothelialization in stented segments are incompletely understood. Once the endothelium is restored, endothelial function might still be impaired. Several strategies have been followed to improve endothelial function after coronary stenting. In this review, the effects of stenting on coronary endothelium are outlined and current and future strategies to improve endothelial function after stent deployment are discussed.

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References

Vane J, Anggard E, Botting R . Regulatory functions of the vascular endothelium. N Engl J Med. 1990; 323(1):27-36. DOI: 10.1056/NEJM199007053230106. View

Van Belle E, Maillard L, Tio F, Isner J . Accelerated endothelialization by local delivery of recombinant human vascular endothelial growth factor reduces in-stent intimal formation. Biochem Biophys Res Commun. 1997; 235(2):311-6. DOI: 10.1006/bbrc.1997.6772. View

Vanhoutte P, Shimokawa H, Tang E, Feletou M . Endothelial dysfunction and vascular disease. Acta Physiol (Oxf). 2009; 196(2):193-222. DOI: 10.1111/j.1748-1716.2009.01964.x. View

Serruys P, Chevalier B, Dudek D, Cequier A, Carrie D, Iniguez A . A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes.... Lancet. 2014; 385(9962):43-54. DOI: 10.1016/S0140-6736(14)61455-0. View

Joner M, Nakazawa G, Finn A, Quee S, Coleman L, Acampado E . Endothelial cell recovery between comparator polymer-based drug-eluting stents. J Am Coll Cardiol. 2008; 52(5):333-42. DOI: 10.1016/j.jacc.2008.04.030. View

Finn A, Kolodgie F, Harnek J, Guerrero L, Acampado E, Tefera K . Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents. Circulation. 2005; 112(2):270-8. DOI: 10.1161/CIRCULATIONAHA.104.508937. View

Sedaghat A, Sinning J, Paul K, Kirfel G, Nickenig G, Werner N . First in vitro and in vivo results of an anti-human CD133-antibody coated coronary stent in the porcine model. Clin Res Cardiol. 2013; 102(6):413-25. DOI: 10.1007/s00392-013-0547-4. View

Ruoslahti E . RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol. 1996; 12:697-715. DOI: 10.1146/annurev.cellbio.12.1.697. View

Ellis S, Kereiakes D, Metzger D, Caputo R, Rizik D, Teirstein P . Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease. N Engl J Med. 2015; 373(20):1905-15. DOI: 10.1056/NEJMoa1509038. View

10.

Farhy R, Carretero O, Ho K, Scicli A . Role of kinins and nitric oxide in the effects of angiotensin converting enzyme inhibitors on neointima formation. Circ Res. 1993; 72(6):1202-10. DOI: 10.1161/01.res.72.6.1202. View

11.

Kastrati A, Mehilli J, Dirschinger J, Dotzer F, Schuhlen H, Neumann F . Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO) trial. Circulation. 2001; 103(23):2816-21. DOI: 10.1161/01.cir.103.23.2816. View

12.

Lee J, Choe W, Kim B, Seo W, Lim W, Kang C . Comparison of endothelialization and neointimal formation with stents coated with antibodies against CD34 and vascular endothelial-cadherin. Biomaterials. 2012; 33(35):8917-27. DOI: 10.1016/j.biomaterials.2012.08.066. View

13.

Lee G, Ikeda R, Joye J, Bogren H, DeMaria A, Mason D . Evaluation of transluminal angioplasty of chronic coronary artery stenosis. Value and limitations assessed in fresh human cadaver hearts. Circulation. 1980; 61(1):77-83. DOI: 10.1161/01.cir.61.1.77. View

14.

KIFOR I, Dzau V . Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins. Circ Res. 1987; 60(3):422-8. DOI: 10.1161/01.res.60.3.422. View

15.

Block P, Baughman K, Pasternak R, Fallon J . Transluminal angioplasty: correlation of morphologic and angiographic findings in an experimental model. Circulation. 1980; 61(4):778-85. DOI: 10.1161/01.cir.61.4.778. View

16.

Nakazawa G, Finn A, Joner M, Ladich E, Kutys R, Mont E . Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. Circulation. 2008; 118(11):1138-45. DOI: 10.1161/CIRCULATIONAHA.107.762047. View

17.

Woudstra P, de Winter R, Beijk M . Next-generation DES: the COMBO dual therapy stent with Genous endothelial progenitor capturing technology and an abluminal sirolimus matrix. Expert Rev Med Devices. 2014; 11(2):121-35. DOI: 10.1586/17434440.2014.882046. View

18.

Gravanis M, Roubin G . Histopathologic phenomena at the site of percutaneous transluminal coronary angioplasty: the problem of restenosis. Hum Pathol. 1989; 20(5):477-85. DOI: 10.1016/0046-8177(89)90014-2. View

19.

Simon C, Palmaz J, Sprague E . Influence of topography on endothelialization of stents: clues for new designs. J Long Term Eff Med Implants. 2000; 10(1-2):143-51. DOI: 10.1615/jlongtermeffmedimplants.v10.i12.120. View

20.

Pasternak R, Baughman K, Fallon J, Block P . Scanning electron microscopy after coronary transluminal angioplasty of normal canine coronary arteries. Am J Cardiol. 1980; 45(3):591-8. DOI: 10.1016/s0002-9149(80)80009-9. View