Serum Vitamin D Deficiency in Children and Adolescents is Associated with Type 1 Diabetes Mellitus

Overview

Journal Endocr Connect

Specialty Endocrinology

Date 2018 Oct 24

PMID 30352405

Citations 13

Authors

Changwei Liu

Jingwen Wang

Yuanyuan Wan

Xiaona Xia

Jian Pan

Wei Gu

Mei Li

Affiliations

Soon will be listed here.

Abstract

Background: To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM).

Methods: A case-control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls.

Results: The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05).

Conclusion: Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children.

Citing Articles

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: a systematic review and meta-analysis.

Yang X, Chai M, Lin M BMC Pediatr. 2024; 24(1):192.

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Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study.

Tan L, Zhong M, Zhao Y, Zhao J, Dusenge M, Feng Y Front Genet. 2023; 14:1230113.

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Vitamin D Status in Diabetic Moroccan Children And Adolescents: a Case-control Study.

Bouichrat N, Benyakhef S, Assarrar I, Draoui N, Lazreg Y, Abda N Rev Diabet Stud. 2023; 19(1):1-7.

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Vitamin D levels and Vitamin D-related gene polymorphisms in Chinese children with type 1 diabetes.

Chen X, Fu J, Qian Y, Zhi X, Pu L, Gu C Front Pediatr. 2022; 10:965296.

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Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children.

He L, Song Y, Zhu T, Gu W, Liu C J Diabetes Res. 2022; 2022:5953562.

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