» Articles » PMID: 30349612

Benefits and Consequences of Testosterone Replacement Therapy: A Review

Overview
Journal Eur Endocrinol
Specialty Endocrinology
Date 2018 Oct 24
PMID 30349612
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Late onset hypogonadism (LOH) is an issue of increasing concern. Studies have shown the importance of testosterone in the maintenance of homeostasis, especially with respect to bone health, sexual function, diabetes, cardiovascular risk, mental health and cognition. Much of the dysfunction in hypogonadism can be reversed or improved with testosterone replacement therapy (TRT). Physicians worry about the possible consequences of TRT, especially regarding the prostate. By reviewing the literature, we have found there are significant benefits to TRT, and fears of adverse effects on the prostate are largely unfounded, though there is a great need for larger studies with longer periods of follow-up, especially to evaluate adverse events.

Citing Articles

Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study.

Collins L, Cole M, Waters T, Iloanya M, Massey P, Sherman W Pathophysiology. 2023; 30(2):123-135.

PMID: 37092525 PMC: 10123744. DOI: 10.3390/pathophysiology30020011.


Testosterone Replacement Therapy in the Aged Male: Monitoring Patients' Quality of Life Utilizing Scoring Systems.

Tsampoukas G, Pang K, Papatsoris A, Moussa M, Miah S Int J Gen Med. 2022; 15:7123-7130.

PMID: 36105846 PMC: 9464626. DOI: 10.2147/IJGM.S253183.


Advancements in the evaluation and treatment for Testosterone Deficiency.

Kresch E, Patel P, Ramasamy R Int J Impot Res. 2022; 34(7):621-622.

PMID: 35388179 DOI: 10.1038/s41443-022-00570-8.

References
1.
Hackett G . Testosterone and the heart. Int J Clin Pract. 2012; 66(7):648-55. DOI: 10.1111/j.1742-1241.2012.02922.x. View

2.
Hyde Z, Norman P, Flicker L, Hankey G, Almeida O, McCaul K . Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men Study. J Clin Endocrinol Metab. 2011; 97(1):179-89. DOI: 10.1210/jc.2011-1617. View

3.
Sarosdy M . Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapy. Cancer. 2006; 109(3):536-41. DOI: 10.1002/cncr.22438. View

4.
Thilers P, MacDonald S, Herlitz A . The association between endogenous free testosterone and cognitive performance: a population-based study in 35 to 90 year-old men and women. Psychoneuroendocrinology. 2006; 31(5):565-76. DOI: 10.1016/j.psyneuen.2005.12.005. View

5.
Kupelian V, Shabsigh R, Travison T, Page S, Araujo A, McKinlay J . Is there a relationship between sex hormones and erectile dysfunction? Results from the Massachusetts Male Aging Study. J Urol. 2006; 176(6 Pt 1):2584-8. DOI: 10.1016/j.juro.2006.08.020. View