Does Cognitive Dysfunction in Bipolar Disorder Qualify As a Diagnostic Intermediate Phenotype?-A Perspective Paper

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2018 Oct 24

PMID 30349492

Citations 3

Authors

Lars Vedel Kessing

Kamilla Miskowiak

Affiliations

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Abstract

The present perspective paper addresses and discusses whether cognitive dysfunction in bipolar disorder qualifies as a diagnostic intermediate phenotype using the Robin and Guze criteria of diagnostic validity. The paper reviews current data within (1) delineation of the clinical intermediate phenotype, (2) associations of the intermediate phenotype with para-clinical data such as brain imaging and blood-based data, (3) associations to family history / genetics, (4) characteristics during long-term follow-up, and (5) treatment effects on cognition. In this way, the paper identifies knowledge gaps and suggests recommendations for future research within each of the five areas. Based on the current state of knowledge, we conclude that cognitive dysfunction does not qualify as a diagnostic intermediate phenotype or endophenotype for bipolar disorder, although promising new evidence points to emotion and reward processing abnormalities as possible putative endophenotypes.

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