Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients

Overview

Journal In Vivo

Specialty Oncology

Date 2018 Oct 24

PMID 30348708

Citations 3

Authors

Tadashi Takenaka

Hideya Yamazaki

Gen Suzuki

Norihiro Aibe

Koji Masui

Daisuke Shimizu

Takeshi Nishimura

Akihiro Nakashima

Toshiyuki Ogata

Keiichiro Matsushita

Ken Yoshida

Kei Yamada

Affiliations

Soon will be listed here.

Abstract

Background/aim: To examine the correlation between dosimetric parameters and acute radiation dermatitis in early breast cancer patients subjected to post-operative radiotherapy.

Patients And Methods: The data of 84 patients treated with post-operative radiotherapy were analyzed. The total prescribed dose was 50 Gy in 25 fractions over 5 weeks. Radiation dermatitis was assessed according to Common Terminology Criteria for Adverse Events v4.0. We set organ at risk whole body (from neck to abdomen examined by CT images) also as surrogate skin volume (3 mm thickness).

Results: A total of 28 patients showed radiation dermatitis grade equal or higher than 2 at the 50 Gy time point. These 28 patients were compared to 56 matched pair patients with grade 0-1 radiation dermatitis during the same treatment period. The mean of V5-20 and V40 in patient's whole volume and V40-50 in skin volume were significantly higher in patients who presented with acute radiation dermatitis Grades ≥2 than in the other patients who did not. The statistically most significant difference was observed for V40 for skin volume and V5 for patient whole volume. Rate of acute radiation dermatitis grade ≥2 was significantly higher for patients with V5 (whole body) >1,360 cm than those with V5 (whole body) <1,360 cm (47% vs. 27%, p=0.0353), as well as for patients with V40 (skin volume) >45 cm compared with those with V40 (skin volume) <45 cm (50% vs. 18%, p=0.0043).

Conclusion: Dosimetric parameters were useful to predict radiation dermatitis grade ≥2. V5 (whole body) 1,360 cm and V40 (skin volume) 45 cm may be dose volume constrain for radiation dermatitis grade ≥2.

Citing Articles

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Intraoperative Radiotherapy with Balloon-Based Electronic Brachytherapy System-A Systematic Review and First Bulgarian Experience in Breast Cancer Patients.

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The Feasibility of Radiation Therapy after Breast-Conserving Surgery for Multiple Ipsilateral Breast Cancer: An Initial Report from ACOSOG Z11102 (Alliance) Trial.

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