A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Oct 24

PMID 30347645

Citations 13

Authors

Francesco Villa

Albino Carrizzo

Anna Ferrario

Anna Maciag

Monica Cattaneo

Chiara Carmela Spinelli

Francesco Montella

Antonio Damato

Elena Ciaglia

Annibale Alessandro Puca

Affiliations

Soon will be listed here.

Abstract

Evolutionary forces select genetic variants that allow adaptation to environmental stresses. The genomes of centenarian populations could recapitulate the evolutionary adaptation model and reveal the secrets of disease resistance shown by these individuals. Indeed, longevity phenotype is supposed to have a genetic background able to survive or escape to age-related diseases. Among these, cardiovascular diseases (CVDs) are the most lethal and their major risk factor is aging and the associated frailty status. One example of genetic evolution revealed by the study of centenarians genome is the four missense Single Nucleotide Polymorphisms (SNPs) haplotype in bactericidal/permeability-increasing fold-containing family B, member 4 (BPIFB4) locus that is enriched in long living individuals: the longevity associated variant (LAV). Indeed, LAV-BPIFB4 is able to improve endothelial function and revascularization through the increase of endothelial nitric oxide synthase (eNOS) dependent nitric oxide production. This review recapitulates the beneficial effects of LAV-BPIFB4 and its therapeutic potential for the treatment of CVDs.

Citing Articles

The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets.

Ciaglia E, Montella F, Carrizzo A, Lopardo V, Esposito R, Basile C Geroscience. 2024; 46(6):6347-6359.

PMID: 38884925 PMC: 11493904. DOI: 10.1007/s11357-024-01242-9.

Longevity-associated BPIFB4 gene counteracts the inflammatory signaling.

Cattaneo M, Baragetti A, Malovini A, Ciaglia E, Lopardo V, Olmastroni E Immun Ageing. 2024; 21(1):19.

PMID: 38468336 PMC: 10929107. DOI: 10.1186/s12979-024-00424-5.

BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice.

Cattaneo M, Aleksova A, Malovini A, Avolio E, Thomas A, Alvino V Cell Death Dis. 2023; 14(8):523.

PMID: 37582912 PMC: 10427721. DOI: 10.1038/s41419-023-06011-8.

Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice.

Giuliani M, Barbi V, Bigossi G, Marcozzi S, Giacconi R, Cardelli M Int J Mol Sci. 2023; 24(7).

PMID: 37047437 PMC: 10095240. DOI: 10.3390/ijms24076464.

The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.

Cattaneo M, Beltrami A, Thomas A, Spinetti G, Alvino V, Avolio E Cardiovasc Res. 2023; 119(7):1583-1595.

PMID: 36635236 PMC: 10318395. DOI: 10.1093/cvr/cvad008.

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