The Relationship Between Inflammatory Factor Expression and Blood Pressure and Urinary Protein in the Placenta of Gestational Hypertension Rats

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2018 Oct 23

PMID 30344654

Citations 3

Authors

Xue-Qin Jia

Su Xu

Mei-Rong Tian

Yu-Yan Ma

Affiliations

Soon will be listed here.

Abstract

The association between inflammatory factor expression and blood pressure with urinary protein in the placenta of pregnant women with pregnancy-induced hypertension (PIH) was investigated to provide a new vision for the clinical prevention and treatment of PIH. Rats were used as animal models and were randomly divided into three groups (control, hypertension and treatment groups) on day 15 of pregnancy with 20 rats in each group. The 10% hypoxia-induced PIH group was induced with administration of an anti-hypertensive drug, and the treatment group was giventreprostinil for one week after the 10% hypoxia-induced PIH. On the 21st day, the experiment was terminated and the placenta was taken to measure the mRNA and protein expression levels of IL-6 and TNF-α, respectively. Pearson's correlation analysis demonstrated the correlation between IL-6 and TNF-α with blood pressure and urinary protein. The blood pressure and urinary protein concentrations in the hypertension group were significantly higher than that in the control group, and the expression levels of IL-6 and TNF-α in the hypertension group were significantly higher (P<0.05). The treatment group significantly reduced inflammatory cytokines and blood pressure and urinary protein levels (P<0.05). Pearson's correlation analysis showed that IL-6 and TNF-α were positively correlated with blood pressure and urinary protein concentration. The blood pressure and urinary protein concentration in PIH rats and the expression levels of IL-6 and TNF-α were significantly higher, and IL-6 and TNF-α were positively correlated with blood pressure and urine protein concentration.

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References

Hermida R, Ayala D, Mojon A, Fernandez J, Alonso I, Silva I . Blood pressure patterns in normal pregnancy, gestational hypertension, and preeclampsia. Hypertension. 2000; 36(2):149-58. DOI: 10.1161/01.hyp.36.2.149. View

Barton J, OBrien J, Bergauer N, Jacques D, Sibai B . Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol. 2001; 184(5):979-83. DOI: 10.1067/mob.2001.112905. View

Vambergue A, Nuttens M, Goeusse P, Biausque S, Lepeut M, Fontaine P . Pregnancy induced hypertension in women with gestational carbohydrate intolerance: the diagest study. Eur J Obstet Gynecol Reprod Biol. 2002; 102(1):31-5. DOI: 10.1016/s0301-2115(01)00556-5. View

Roberts J, Redman C . Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 1993; 341(8858):1447-51. DOI: 10.1016/0140-6736(93)90889-o. View

Peracoli J, Rudge M, Peracoli M . Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsia. Am J Reprod Immunol. 2007; 57(3):177-85. DOI: 10.1111/j.1600-0897.2006.00455.x. View

Redman C, Sargent I . Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review. Placenta. 2003; 24 Suppl A:S21-7. DOI: 10.1053/plac.2002.0930. View

Koopmans C, Bijlenga D, Groen H, Vijgen S, Aarnoudse J, Bekedam D . Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial. Lancet. 2009; 374(9694):979-988. DOI: 10.1016/S0140-6736(09)60736-4. View

Ros H, Cnattingius S, Lipworth L . Comparison of risk factors for preeclampsia and gestational hypertension in a population-based cohort study. Am J Epidemiol. 1998; 147(11):1062-70. DOI: 10.1093/oxfordjournals.aje.a009400. View

Xiong X, Demianczuk N, Saunders L, Wang F, Fraser W . Impact of preeclampsia and gestational hypertension on birth weight by gestational age. Am J Epidemiol. 2002; 155(3):203-9. DOI: 10.1093/aje/155.3.203. View

10.

Borzychowski A, Sargent I, Redman C . Inflammation and pre-eclampsia. Semin Fetal Neonatal Med. 2006; 11(5):309-16. DOI: 10.1016/j.siny.2006.04.001. View

11.

Buchbinder A, Sibai B, Caritis S, MacPherson C, Hauth J, Lindheimer M . Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol. 2002; 186(1):66-71. DOI: 10.1067/mob.2002.120080. View

12.

NAEYE R, Friedman E . Causes of perinatal death associated with gestational hypertension and proteinuria. Am J Obstet Gynecol. 1979; 133(1):8-10. DOI: 10.1016/0002-9378(79)90402-2. View

13.

Sibai B . Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003; 102(1):181-92. DOI: 10.1016/s0029-7844(03)00475-7. View

14.

Sargent I, Borzychowski A, Redman C . NK cells and human pregnancy--an inflammatory view. Trends Immunol. 2006; 27(9):399-404. DOI: 10.1016/j.it.2006.06.009. View

15.

Seely E, Solomon C . Insulin resistance and its potential role in pregnancy-induced hypertension. J Clin Endocrinol Metab. 2003; 88(6):2393-8. DOI: 10.1210/jc.2003-030241. View

16.

Hermida R, Ayala D, Mojon A, Fernandez J, Silva I, Ucieda R . Blood pressure excess for the early identification of gestational hypertension and preeclampsia. Hypertension. 1998; 31(1):83-9. DOI: 10.1161/01.hyp.31.1.83. View

17.

Sgambati E, Marini M, Zappoli Thyrion G, Parretti E, Mello G, Orlando C . VEGF expression in the placenta from pregnancies complicated by hypertensive disorders. BJOG. 2004; 111(6):564-70. DOI: 10.1111/j.1471-0528.2004.00143.x. View

18.

LaMarca B, Ryan M, Gilbert J, Murphy S, Granger J . Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia. Curr Hypertens Rep. 2008; 9(6):480-5. DOI: 10.1007/s11906-007-0088-1. View

19.

Salonen Ros H, Lichtenstein P, Lipworth L, Cnattingius S . Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet. 2000; 91(4):256-60. View