Interleukin-1 Beta and Tumor Necrosis Factor Alpha Upregulation and Nuclear Factor Kappa B Activation in Skeletal Muscle from a Mouse Model of Chronic/Progressive Parkinson Disease

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2018 Oct 23

PMID 30344306

Citations 12

Authors

Nour Erekat

Muhammed D Al-Jarrah

Affiliations

Soon will be listed here.

Abstract

BACKGROUND Skeletal muscle atrophy has been reported in patients with Parkinson disease (PD). The purpose of this study was to examine the potential implication of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNFα), and nuclear factor kappa B (NF kappa B) in skeletal muscle atrophy following PD induction. MATERIAL AND METHODS Chronic Parkinsonism was induced in 10 albino mice by MPTP/probenecid treatment, while 10 other albino mice remained without treatment and were subsequently used as controls. Gastrocnemius muscles were examined for the expression of IL-1β and TNF-α, as well as the nuclear localization of NF kappa B, indicative of its activation, using immunohistochemistry in the 2 different groups. RESULTS IL-1β and TNF-α expression and NF kappa B nuclear localization were significantly higher in the PD skeletal muscle compared with those in the controls (P value <0.01). CONCLUSIONS The present data are indicative of an association of PD with IL-1β and TNF-α upregulation and NF kappa B activation in gastrocnemius muscles, potentially promoting the atrophy frequently observed in PD.

Citing Articles

The role of osteopontin and osteocyte-derived factors in secondary hyperparathyroidism-induced myopathy.

Duque E, Crispilho S, Oliveira I, Dominguez W, Silva C, Furukawa L JBMR Plus. 2024; 8(8):ziae084.

PMID: 39070237 PMC: 11273725. DOI: 10.1093/jbmrpl/ziae084.

Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice.

Ko J, Chang B, Choi Y, Choi J, Kwon H, Lee J Nutrients. 2024; 16(1).

PMID: 38201986 PMC: 10781061. DOI: 10.3390/nu16010157.

LPS-Induced Modifications in Macrophage Transcript and Secretion Profiles Are Linked to Muscle Wasting and Glucose Intolerance.

Ryu H, Jeong H, Lee S, Lee M, Kim M, Lee B J Microbiol Biotechnol. 2023; 34(2):270-279.

PMID: 38044678 PMC: 10940789. DOI: 10.4014/jmb.2309.09037.

Empagliflozin repurposing in Parkinson's disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways.

Mohammed N, Tadros M, George M Inflammopharmacology. 2023; 32(1):777-794.

PMID: 38038781 PMC: 10907444. DOI: 10.1007/s10787-023-01384-w.

The role of exercise in Parkinson's Disease.

Almikhlafi M Neurosciences (Riyadh). 2023; 28(1):4-12.

PMID: 36617448 PMC: 9987629. DOI: 10.17712/nsj.2023.1.20220105.

References

Adams V, Jiang H, Yu J, Mobius-Winkler S, Fiehn E, Linke A . Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. J Am Coll Cardiol. 1999; 33(4):959-65. DOI: 10.1016/s0735-1097(98)00626-3. View

Thaloor D, Miller K, Gephart J, Mitchell P, Pavlath G . Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am J Physiol. 1999; 277(2):C320-9. DOI: 10.1152/ajpcell.1999.277.2.C320. View

Liberatore G, Jackson-Lewis V, Vukosavic S, Mandir A, Vila M, McAuliffe W . Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med. 1999; 5(12):1403-9. DOI: 10.1038/70978. View

Langen R, Schols A, Kelders M, Wouters E . Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J. 2001; 15(7):1169-80. DOI: 10.1096/fj.00-0463. View

Reid M, Li Y . Tumor necrosis factor-alpha and muscle wasting: a cellular perspective. Respir Res. 2001; 2(5):269-72. PMC: 59514. DOI: 10.1186/rr67. View

Hacham M, Argov S, White R, Segal S, Apte R . Different patterns of interleukin-1alpha and interleukin-1beta expression in organs of normal young and old mice. Eur Cytokine Netw. 2002; 13(1):55-65. View

Parkinson J . An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci. 2002; 14(2):223-36; discussion 222. DOI: 10.1176/jnp.14.2.223. View

Adams V, Nehrhoff B, Spate U, Linke A, Schulze P, Baur A . Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study. Cardiovasc Res. 2002; 54(1):95-104. DOI: 10.1016/s0008-6363(02)00228-6. View

Schulze P, Gielen S, Schuler G, Hambrecht R . Chronic heart failure and skeletal muscle catabolism: effects of exercise training. Int J Cardiol. 2002; 85(1):141-9. DOI: 10.1016/s0167-5273(02)00243-7. View

10.

Monici M, Aguennouz M, Mazzeo A, Messina C, Vita G . Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology. 2003; 60(6):993-7. DOI: 10.1212/01.wnl.0000049913.27181.51. View

11.

Mackiewicz Z, Hukkanen M, Povilenaite D, Sukura A, Fonseca J, Virtanen I . Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies. Clin Exp Rheumatol. 2003; 21(1):41-8. View

12.

Gielen S, Adams V, Mobius-Winkler S, Linke A, Erbs S, Yu J . Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003; 42(5):861-8. DOI: 10.1016/s0735-1097(03)00848-9. View

13.

Sakkas G, Ball D, Mercer T, Sargeant A, Tolfrey K, Naish P . Atrophy of non-locomotor muscle in patients with end-stage renal failure. Nephrol Dial Transplant. 2003; 18(10):2074-81. DOI: 10.1093/ndt/gfg325. View

14.

Klivenyi P, Gardian G, Calingasan N, Yang L, Beal M . Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. J Mol Neurosci. 2003; 21(3):191-8. DOI: 10.1385/jmn:21:3:191. View

15.

Shen Y, Hebert G, Lin L, Luo Y, Moze E, Li K . Interleukine-1beta and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization. J Neuroimmunol. 2004; 158(1-2):14-25. DOI: 10.1016/j.jneuroim.2004.06.011. View

16.

Zhang J, Peng B, Chen X . Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. Clin Cancer Res. 2005; 11(20):7334-43. DOI: 10.1158/1078-0432.CCR-05-0241. View

17.

Przybyla B, Gurley C, Harvey J, Bearden E, Kortebein P, Evans W . Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. Exp Gerontol. 2006; 41(3):320-7. DOI: 10.1016/j.exger.2005.12.007. View

18.

Boehm A, Seth M, Mayr K, Fortier L . Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes. Arthritis Rheum. 2007; 56(7):2335-43. DOI: 10.1002/art.22664. View

19.

Doppler K, Mittelbronn M, Bornemann A . Myogenesis in human denervated muscle biopsies. Muscle Nerve. 2007; 37(1):79-83. DOI: 10.1002/mus.20902. View

20.

Potashkin J, Kang U, Loomis P, Jodelka F, Ding Y, Meredith G . MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9. Brain Res. 2007; 1182:1-10. DOI: 10.1016/j.brainres.2007.08.080. View