Relationship Between Polymorphisms of the Lipid Metabolism-related Gene PLA2G16 and Risk of Colorectal Cancer in the Chinese Population

Overview

Journal Funct Integr Genomics

Publisher Springer

Specialties Genetics
Molecular Biology

Date 2018 Oct 22

PMID 30343388

Citations 2

Authors

Xiao-Nv Xie

Jing Yu

Li-Hua Zhang

Zhi-Ying Luo

Dong-Sheng Ouyang

Ling-Jie Zheng

Chun-Yang Wang

Li Yang

Ling Chen

Zhi-Rong Tan

Affiliations

Soon will be listed here.

Abstract

This study aimed to investigate the relationship between polymorphisms in the lipid metabolism-related gene PLA2G16 encoding Group XVI phospholipase A2 and the risk of colorectal cancer (CRC) in the Chinese population. A total of 185 patients with CRC and 313 healthy controls were enrolled. Thirteen single nucleotide polymorphisms (SNPs) of PLA2G16 were genotyped with SNPscan™. Linkage disequilibrium and haplotypes were analysed using Haploview software. Multivariate logistic regression was used to determine the association between the various genotypes and CRC risk. We identified five PLA2G16 SNPs (rs11600655, rs3809072, rs3809073, rs640908 and rs66475048) that were associated with CRC risk after adjusting for age, sex and body mass index. Two haplotypes (CTC and GGA) of rs11600655, rs3809073 and rs3809072, were relevant to CRC risk. The rs11600655 polymorphism was also associated with lymph node metastasis and CRC staging, while rs3809073 and rs3809072 may affect transcriptional regulation of PLA2G16 by altering transcription factor binding. These findings suggest that PLA2G16 polymorphisms-especially CTC and GGA haplotypes-increase CRC susceptibility. Importantly, we showed that the rs11600655 CC, rs640908 CT and rs66475048 GA genotypes are independent risk factors for CRC in the Chinese population.

Citing Articles

Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network.

Zhu H, Ji Y, Li W, Wu M Oncol Lett. 2019; 18(4):3778-3786.

PMID: 31579079 PMC: 6757265. DOI: 10.3892/ol.2019.10698.

The role of PEG3 in the occurrence and prognosis of colon cancer.

Zhou T, Lin W, Zhu Q, Renaud H, Liu X, Li R Onco Targets Ther. 2019; 12:6001-6012.

PMID: 31413595 PMC: 6662866. DOI: 10.2147/OTT.S208060.

References

Sheehan K, Sheahan K, ODonoghue D, MacSweeney F, Conroy R, Fitzgerald D . The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA. 1999; 282(13):1254-7. DOI: 10.1001/jama.282.13.1254. View

Yuan C, Mandal A, Zhang Z, Mukherjee A . Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs. Cancer Res. 2000; 60(4):1084-91. View

Sers C, Husmann K, Nazarenko I, Reich S, Wiechen K, Zhumabayeva B . The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. Oncogene. 2002; 21(18):2829-39. DOI: 10.1038/sj.onc.1205377. View

Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B . Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell. 2004; 6(3):285-95. DOI: 10.1016/j.ccr.2004.08.011. View

Westbrook T, Martin E, Schlabach M, Leng Y, Liang A, Feng B . A genetic screen for candidate tumor suppressors identifies REST. Cell. 2005; 121(6):837-48. DOI: 10.1016/j.cell.2005.03.033. View

Coulson J . Transcriptional regulation: cancer, neurons and the REST. Curr Biol. 2005; 15(17):R665-8. DOI: 10.1016/j.cub.2005.08.032. View

Castellone M, Teramoto H, Williams B, Druey K, Gutkind J . Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science. 2005; 310(5753):1504-10. DOI: 10.1126/science.1116221. View

Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q . CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med. 2006; 203(4):941-51. PMC: 2118273. DOI: 10.1084/jem.20052124. View

Nazarenko I, Kristiansen G, Fonfara S, Guenther R, Gieseler C, Kemmner W . H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling. Am J Pathol. 2006; 169(4):1427-39. PMC: 1698850. DOI: 10.2353/ajpath.2006.051341. View

10.

Nazarenko I, Schafer R, Sers C . Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells. J Cell Sci. 2007; 120(Pt 8):1393-404. DOI: 10.1242/jcs.000018. View

11.

Wong H, Koh W, Probst-Hensch N, van den Berg D, Yu M, Ingles S . Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach. Gut. 2008; 57(8):1090-6. PMC: 2752962. DOI: 10.1136/gut.2007.140855. View

12.

Wang D, DuBois R . Pro-inflammatory prostaglandins and progression of colorectal cancer. Cancer Lett. 2008; 267(2):197-203. PMC: 2553688. DOI: 10.1016/j.canlet.2008.03.004. View

13.

Duncan R, Sarkadi-Nagy E, Jaworski K, Ahmadian M, Sul H . Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA). J Biol Chem. 2008; 283(37):25428-25436. PMC: 2533091. DOI: 10.1074/jbc.M804146200. View

14.

Kaklamani V, Wisinski K, Sadim M, Gulden C, Do A, Offit K . Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA. 2008; 300(13):1523-31. PMC: 2628475. DOI: 10.1001/jama.300.13.1523. View

15.

Jaworski K, Ahmadian M, Duncan R, Sarkadi-Nagy E, Varady K, Hellerstein M . AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med. 2009; 15(2):159-68. PMC: 2863116. DOI: 10.1038/nm.1904. View

16.

Hawken S, Greenwood C, Hudson T, Kustra R, Mclaughlin J, Yang Q . The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hum Genet. 2010; 128(1):89-101. PMC: 2885303. DOI: 10.1007/s00439-010-0828-1. View

17.

Tania M, Khan M, Song Y . Association of lipid metabolism with ovarian cancer. Curr Oncol. 2010; 17(5):6-11. PMC: 2949373. DOI: 10.3747/co.v17i5.668. View

18.

van Duijnhoven F, Bueno-de-Mesquita H, Calligaro M, Jenab M, Pischon T, Jansen E . Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition. Gut. 2011; 60(8):1094-102. DOI: 10.1136/gut.2010.225011. View

19.

Boyle A, Hong E, Hariharan M, Cheng Y, Schaub M, Kasowski M . Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 2012; 22(9):1790-7. PMC: 3431494. DOI: 10.1101/gr.137323.112. View

20.

Peng Y, Li X, Wu M, Yang J, Liu M, Zhang W . New prognosis biomarkers identified by dynamic proteomic analysis of colorectal cancer. Mol Biosyst. 2012; 8(11):3077-88. DOI: 10.1039/c2mb25286d. View