An African Perspective on the Genetic Risk of Chronic Kidney Disease: a Systematic Review

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2018 Oct 21

PMID 30340464

Citations 11

Authors

Cindy George

Yandiswa Y Yako

Ikechi G Okpechi

Tandi E Matsha

Francois J Kaze Folefack

Andre P Kengne

Affiliations

Soon will be listed here.

Abstract

Background: Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking.

Methods: We conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits. Given the very few studies investigating the effects of the same single nucleotide polymorphisms (SNPs) on CKD risk, a narrative synthesis of the evidence was conducted.

Results: A total of 30 polymorphisms in 11 genes were investigated for their association with CKD, ESRD or related traits, all using the candidate-gene approach. Of all the included genes, MYH9, AT1R and MTHFR genes failed to predict CKD or related traits, while variants in the APOL1, apoE, eNOS, XPD, XRCC1, renalase, ADIPOQ, and CCR2 genes were associated with CKD or other related traits. Two SNPs (rs73885319, rs60910145) and haplotypes (G-A-G; G1; G2) of the apolipoprotein L1 (APOL1) gene were studied in more than one population group, with similar association with prevalent CKD observed. The remaining polymorphisms were investigated in single studies.

Conclusion: According to this systematic review, there is currently insufficient evidence of the specific polymorphisms that poses African populations at an increased risk of CKD. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms, specific to African populations.

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References

Matsha T, Kengne A, Masconi K, Yako Y, Erasmus R . APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans. BMC Genet. 2015; 16:69. PMC: 4482162. DOI: 10.1186/s12863-015-0228-6. View

Hanna M, Shahin R, Meshaal S, Kostandi I . Susceptibility and progression of end stage renal disease are not associated with angiotensin II type 1 receptor gene polymorphism. J Recept Signal Transduct Res. 2014; 35(5):381-5. DOI: 10.3109/10799893.2014.956757. View

Rezk N, Zidan H, Elnaggar Y, Ghorab A . Renalase gene polymorphism and epinephrine level in chronic kidney disease. Appl Biochem Biotechnol. 2014; 175(4):2309-17. DOI: 10.1007/s12010-014-1433-x. View

Genovese G, Friedman D, Pollak M . APOL1 variants and kidney disease in people of recent African ancestry. Nat Rev Nephrol. 2013; 9(4):240-4. DOI: 10.1038/nrneph.2013.34. View

OSeaghdha C, Fox C . Genome-wide association studies of chronic kidney disease: what have we learned?. Nat Rev Nephrol. 2011; 8(2):89-99. PMC: 4769862. DOI: 10.1038/nrneph.2011.189. View

Estrella M, Li M, Tin A, Abraham A, Shlipak M, Penugonda S . The association between APOL1 risk alleles and longitudinal kidney function differs by HIV viral suppression status. Clin Infect Dis. 2014; 60(4):646-52. PMC: 4318914. DOI: 10.1093/cid/ciu765. View

Roussos L, Flor n C, Carlson J, Svensson P, Wallmark A, Ekberg H . Increased prevalence of apolipoprotein E3/E4 genotype among Swedish renal transplant recipients. Nephron. 1999; 83(1):25-30. DOI: 10.1159/000045469. View

Elshamaa M, Sabry S, El-Sonbaty M, Elghoroury E, Emara N, Raafat M . Adiponectin: an adipocyte-derived hormone, and its gene encoding in children with chronic kidney disease. BMC Res Notes. 2012; 5:174. PMC: 3403889. DOI: 10.1186/1756-0500-5-174. View

Noiri E, Satoh H, Taguchi J, Brodsky S, Nakao A, Ogawa Y . Association of eNOS Glu298Asp polymorphism with end-stage renal disease. Hypertension. 2002; 40(4):535-40. DOI: 10.1161/01.hyp.0000033974.57407.82. View

10.

Bryc K, Velez C, Karafet T, Moreno-Estrada A, Reynolds A, Auton A . Colloquium paper: genome-wide patterns of population structure and admixture among Hispanic/Latino populations. Proc Natl Acad Sci U S A. 2010; 107 Suppl 2:8954-61. PMC: 3024022. DOI: 10.1073/pnas.0914618107. View

11.

El-Shal A, Zidan H, Rashad N . Adiponectin gene polymorphisms in Egyptian type 2 diabetes mellitus patients with and without diabetic nephropathy. Mol Biol Rep. 2014; 41(4):2287-98. DOI: 10.1007/s11033-014-3082-0. View

12.

Sanchez-Quinto F, Botigue L, Civit S, Arenas C, Avila-Arcos M, Bustamante C . North African populations carry the signature of admixture with Neandertals. PLoS One. 2012; 7(10):e47765. PMC: 3474783. DOI: 10.1371/journal.pone.0047765. View

13.

Elshamaa M, Sabry S, Badr A, El-Ahmady M, Elghoroury E, Thabet E . Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with chronic kidney disease. Blood Coagul Fibrinolysis. 2011; 22(6):487-92. DOI: 10.1097/MBC.0b013e328346ef71. View

14.

Trabulus S, Guven G, Altiparmak M, Batar B, Tun O, Yalin A . DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease. Mol Biol Rep. 2012; 39(6):6995-7001. DOI: 10.1007/s11033-012-1529-8. View

15.

Tzur S, Rosset S, Shemer R, Yudkovsky G, Selig S, Tarekegn A . Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Hum Genet. 2010; 128(3):345-50. PMC: 2921485. DOI: 10.1007/s00439-010-0861-0. View

16.

Tishkoff S, Reed F, Friedlaender F, Ehret C, Ranciaro A, Froment A . The genetic structure and history of Africans and African Americans. Science. 2009; 324(5930):1035-44. PMC: 2947357. DOI: 10.1126/science.1172257. View

17.

OSeaghdha C, Parekh R, Hwang S, Li M, Kottgen A, Coresh J . The MYH9/APOL1 region and chronic kidney disease in European-Americans. Hum Mol Genet. 2011; 20(12):2450-6. PMC: 3098737. DOI: 10.1093/hmg/ddr118. View

18.

Cohen D, Townsend R . Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans?. J Clin Hypertens (Greenwich). 2013; 15(7):445-6. PMC: 8033862. DOI: 10.1111/jch.12126. View

19.

Hsu C, Lin F, Vittinghoff E, Shlipak M . Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States. J Am Soc Nephrol. 2003; 14(11):2902-7. DOI: 10.1097/01.asn.0000091586.46532.b4. View

20.

Colares V, Titan S, Pereira A, Malafronte P, Cardena M, Santos S . MYH9 and APOL1 gene polymorphisms and the risk of CKD in patients with lupus nephritis from an admixture population. PLoS One. 2014; 9(3):e87716. PMC: 3962338. DOI: 10.1371/journal.pone.0087716. View