Microemulsion-based Hydrogels for Enhancing Epidermal/dermal Deposition of Topically Administered 20()-protopanaxadiol: and Evaluation Studies

Overview

Journal J Ginseng Res

Date 2018 Oct 20

PMID 30337812

Citations 12

Authors

Ki-Taek Kim

Min-Hwan Kim

Ju-Hwan Park

Jae-Young Lee

Hyun-Jong Cho

In-Soo Yoon

Dae-Duk Kim

Affiliations

Soon will be listed here.

Abstract

Background: 20()-Protopanaxadiol (20-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal antiaging activity. However, because of its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20-PPD.

Methods: MEs and MEHs were formulated and evaluated for their particle size distribution, morphology, drug loading capacity, and stability. Then, the deposition profiles of the selected 20-PPD-loaded MEH formulation were studied using a hairless mouse skin model and Strat-M membrane as an artificial skin model.

Results: A Carbopol-based MEH system of 20-PPD was successfully prepared with a mean droplet size of 110 nm and narrow size distribution. The formulation was stable for 56 d, and its viscosity was high enough for its topical application. It significantly enhanced the and skin deposition of 20-PPD with no influence on its systemic absorption in hairless mice. Notably, it was found that the Strat-M membrane provided skin deposition data well correlated to those obtained from the and mouse skin studies on 20-PPD (correlation coefficient = 0.929‒0.947).

Conclusion: The MEH formulation developed in this study could serve as an effective topical delivery system for poorly soluble ginsenosides and their deglycosylated metabolites, including 20-PPD.

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