Influence of Membrane Polarization and Hormonal Stimulation on the Action of Lanthanum on Frog Skin Sodium Permeability

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1977 Aug 29

PMID 303349

Citations 4

Authors

J Wietzerbin

H GOUDEAU

Affiliations

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Abstract

The effect of mucosal La3+ on short-circuit current (s.c.c.) has been studied on isolated frog skins with normaly polarized or depolarized apical membrane. With skins in "polarized condition", La3+ stimulates transiently the s.c.c. and after a long-lasting presence on the mucosal side (1 h) attenuates significantly the stimulation promoted by oxytocin. With skins in "depolarized conditions", lanthanum stimulates permanently the s.c.c. and does not modifying the oxytocin effect, even over long period of continuous stimulation. In contrast, an inhibitory action of mucosal La3+ develops, when skins submitted to repetitive hormonal stimulation are forced to oscillate from the stimulated to the normal resting state. The significance of this particular mode of action is discussed in terms of a possible electrical potential variation of apical membrane during oxytocin stimulation.

Citing Articles

Surface potentials and sodium entry in frog skin epithelium.

Benos D, Latorre R, Reyes J J Physiol. 1981; 321:163-74.

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Effect of FeCl3 on ion transport in isolated frog skin.

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Microelectrode studies of the effect of lanthanum on the electrical potential and resistance of outer and inner cell membranes of isolated frog skin.

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PMID: 6281435 DOI: 10.1007/BF01868488.

Effects of mucosal lanthanum on electrical parameters of isolated frog skin. Mechanism of action.

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