The Roles of and Gene Polymorphisms in Congenital Heart Diseases: a Meta-analysis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Oct 19

PMID 30333252

Citations 10

Authors

Aiping Xu

Weiping Wang

Xiaolei Jiang

Affiliations

Soon will be listed here.

Abstract

We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase () and methionine synthase reductase () gene polymorphisms with the risk of congenital heart diseases (CHD). Eligible articles were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations of and gene polymorphisms with CHD. A total of 47 eligible studies were finally included in our meta-analysis. Our overall analyses suggested that rs1801394, rs1532268, rs1801131 and rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models. Further subgroup analyses according to ethnicity of study participants demonstrated that the rs1801394 polymorphism was significantly correlated with the risk of CHD only in Asians, whereas rs1532268, rs1801133 and rs1801131 polymorphisms were significantly correlated with the risk of CHD in both Asians and Caucasians. Our findings indicated that rs1532268, rs1801131 and rs1801133 polymorphisms may affect the risk of CHD in Asians and Caucasians, while the rs1801394 polymorphism may only affect in risk of CHD in Asians.

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