Evaluation of Hematological Parameters in Children with FMF

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2018 Oct 18

PMID 30328023

Citations 1

Authors

Alaaddin Yorulmaz

Hikmet Akbulut

Suna Adeviye Tas

Merve Tiras

Ibaa Yahya

Harun Peru

Affiliations

Soon will be listed here.

Abstract

In this study, we aimed to investigate whether neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) might be helpful in the diagnosis of subclinical inflammation of familial Mediterranean fever (FMF). Clinical, laboratory, and genetic results of the patients who were followed up with the diagnosis of FMF were obtained retrospectively from the hospital files and recorded to standardized form. Age- and sex-matched healthy subjects were included as the control group. Eighty-three of the 143 patients (58.0%) were male and 60 (42.0%) were female. The mean age of our patients was 164.62 ± 51.20 months and the mean age of the control group was 164.92 ± 51.10 months. The mean diagnosis age of our patients was 98.10 ± 49.11 months. The mean follow-up time of the patients was 66.03 ± 36.37 months. 91.60% of our patients had abdominal pain, 78.32% fever, and 28.67% joint pain. The mean NLR of the patients was significantly higher than the mean levels at attack-free period and the control group. However, no statistically significant difference was found between the mean levels at attack-free period and the control group. MPV levels were statistically significantly high during acute attack when compared with the control group. However, they showed no statistically significant difference between acute attack and attack-free period. NLR is a useful marker to predict inflammation in FMF patients. However, our results did not support the idea that MPV might reflect acute attack and attack-free period.

Citing Articles

Pan-Immune-Inflammation Value Could Be a New Marker to Predict Amyloidosis and Disease Severity in Familial Mediterranean Fever.

Ocak T, Gorunen A, Coskun B, Yagiz B, Sag S, Ocakoglu G Diagnostics (Basel). 2024; 14(6).

PMID: 38535054 PMC: 10968919. DOI: 10.3390/diagnostics14060634.

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