Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic...

Overview

Journal Pancreas

Specialty Gastroenterology

Date 2018 Oct 17

PMID 30325863

Citations 18

Authors

Phil A Hart

Dana K Andersen

Kieren J Mather

Alicia C Castonguay

Mandeep Bajaj

Melena D Bellin

David Bradley

Noemy Contreras

Aida Habtezion

Murray Korc

Yogish Kudva

Maxim S Petrov

David C Whitcomb

Dhiraj Yadav

Ying Yuan

Jo Ann S Rinaudo

Sudhir Srivastava

Jose Serrano

Mark O Goodarzi

Affiliations

Soon will be listed here.

Abstract

Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, "Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study," that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.

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