Physical Activity and Epigenetic Biomarkers in Maternal Blood During Pregnancy

Overview

Journal Epigenomics

Specialty Genetics

Date 2018 Oct 17

PMID 30324807

Citations 5

Authors

Sylvia E Badon

Alyson J Littman

Kwun Chuen Gary Chan

Mahlet G Tadesse

Patricia L Stapleton

Theo K Bammler

Tanya K Sorensen

Michelle A Williams

Daniel A Enquobahrie

Affiliations

Soon will be listed here.

Abstract

Aim: Investigate associations of leisure time physical activity (LTPA) with DNA methylation and miRNAs during pregnancy. Patients & methods: LTPA, candidate DNA methylation and circulating miRNAs were measured (average 15 weeks gestation) in pregnant women (n = 92).

Results: Each additional hour of prepregnancy LTPA duration was associated with hypermethylation in C1orf212 (β = 0.137, 95% CI: 0.004-0.270) and higher circulating miR-146b-5p (β = 0.084, 95% CI: 0.017-0.151). Each additional metabolic equivalent hour of early-pregnancy LTPA energy expenditure was associated with higher circulating miR-21-3p (β = 0.431, 95% CI: 0.089-0.772) in women carrying female offspring, and lower circulating miR-146b-5p (β = -0.285, 95% CI: -0.528 to -0.043) and miR-517-5p (β = -0.406, 95% CI: -0.736 to -0.076) in women carrying male offspring.

Conclusion: Our findings suggest that LTPA may influence maternal epigenetic biomarkers, possibly in an offspring sex-specific manner.

Citing Articles

Exploring the role of exosomal MicroRNAs as potential biomarkers in preeclampsia.

Shan Y, Hou B, Wang J, Chen A, Liu S Front Immunol. 2024; 15:1385950.

PMID: 38566996 PMC: 10985148. DOI: 10.3389/fimmu.2024.1385950.

Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event.

Andrawus M, Sharvit L, Atzmon G Int J Mol Sci. 2022; 23(20).

PMID: 36293556 PMC: 9603966. DOI: 10.3390/ijms232012698.

Level of Physical Activity in Pregnant Populations from Different Geographic Regions: A Systematic Review.

Silva-Jose C, Sanchez-Polan M, Barakat R, Gil-Ares J, Refoyo I J Clin Med. 2022; 11(15).

PMID: 35956253 PMC: 9369818. DOI: 10.3390/jcm11154638.

Mothers' and fathers' cognitive and affective responses to epigenetics concepts.

Hollister B, Yaremych H, Goldring M, Persky S Environ Epigenet. 2020; 5(4):dvz021.

PMID: 33244405 PMC: 6875654. DOI: 10.1093/eep/dvz021.

Leisure Time Physical Activity, Sedentary Time in Pregnancy, and Infant Weight at Approximately 12 Months.

Badon S, Littman A, Chan K, Williams M, Kirkegaard H, Nohr E Womens Health Rep (New Rochelle). 2020; 1(1):123-131.

PMID: 32617532 PMC: 7325488. DOI: 10.1089/whr.2020.0068.

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