Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides As Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment

Overview

Journal Nucleic Acid Ther

Specialties Biochemistry
Molecular Biology
Pharmacology

Date 2018 Oct 12

PMID 30307373

Citations 45

Authors

Michael J Gait

Andrey A Arzumanov

Graham McClorey

Caroline Godfrey

Corinne Betts

Suzan Hammond

Matthew J A Wood

Affiliations

Soon will be listed here.

Abstract

The review starts with a historical perspective of the achievements of the Gait group in synthesis of oligonucleotides (ONs) and their peptide conjugates toward the award of the 2017 Oligonucleotide Therapeutic Society Lifetime Achievement Award. This acts as a prelude to the rewarding collaborative studies in the Gait and Wood research groups aimed toward the enhanced delivery of charge neutral ON drugs and the development of a series of Arg-rich cell-penetrating peptides called Pip (peptide nucleic acid/phosphorodiamidate morpholino oligonucleotide [PNA/PMO] internalization peptides) as conjugates of such ONs. In this review we concentrate on these developments toward the treatment of the neuromuscular diseases Duchenne muscular dystrophy and spinal muscular atrophy toward a platform technology for the enhancement of cellular and in vivo delivery suitable for widespread use as neuromuscular and neurodegenerative ON drugs.

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