Acute Continuous Moderate-intensity Exercise, but Not Low-volume High-intensity Interval Exercise, Attenuates Postprandial Suppression of Circulating Osteocalcin in Young Overweight and Obese Adults

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2018 Oct 12

PMID 30306222

Citations 3

Authors

L Parker

C S Shaw

E Byrnes

N K Stepto

I Levinger

Affiliations

Soon will be listed here.

Abstract

Introduction: Acute exercise transiently increases BRMs including osteocalcin (tOC) and the undercarboxylated form of osteocalcin (ucOC), a hormone that is implicated in glucose regulation. The effects of acute exercise and exercise-intensity on postprandial levels of tOC and ucOC are unknown.

Methods: Twenty-seven adults that were overweight or obese (age 30 ± 1 years; BMI 30 ± 1 kg∙m; mean ± SEM) were randomly allocated to perform a single session of low-volume high-intensity interval exercise (LV-HIIE; nine females, five males) or continuous moderate-intensity exercise (CMIE; eightfemales, five males) 1 h after consumption of a standard breakfast. Serum tOC, ucOC, and ucOC/tOC were measured at baseline, 1 h, and 3 h after breakfast consumption on a rest day (no exercise) and the exercise day (exercise 1 h after breakfast).

Results: Compared to baseline, serum tOC and ucOC were suppressed 3 h after breakfast on the rest day (- 10 ± 1% and - 6 ± 2%, respectively; p < 0.05), whereas ucOC/tOC was elevated (2.5 ± 1%; p = 0.08). Compared to the rest day, CMIE attenuated the postprandial-induced suppression of tOC (rest day - 10 ± 2% versus CMIE - 5 ± 2%, p < 0.05) and ucOC (rest day - 6 ± 4% versus CMIE 11 ± 2%, p < 0.05), and increased postprandial ucOC/tOC (rest day 3 ± 2% versus CMIE 15 ± 1%, p < 0.05). In contrast, LV-HIIE did not alter postprandial tOC, ucOC, or ucOC/tOC (all p > 0.1).

Conclusions: Acute CMIE, but not LV-HIIE, attenuates the postprandial-induced suppression of tOC and ucOC. CMIE may be an effective tool to control the circulating levels of BRMs following meal consumption in overweight/obese adults.

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References

Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S . Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2008; 94(1):45-9. DOI: 10.1210/jc.2008-1455. View

Jiao H, Xiao E, Graves D . Diabetes and Its Effect on Bone and Fracture Healing. Curr Osteoporos Rep. 2015; 13(5):327-35. PMC: 4692363. DOI: 10.1007/s11914-015-0286-8. View

Zhou B, Li H, Liu J, Xu L, Guo Q, Zang W . Autophagic dysfunction is improved by intermittent administration of osteocalcin in obese mice. Int J Obes (Lond). 2016; 40(5):833-43. DOI: 10.1038/ijo.2016.1. View

Lopes L, Schwartz R, Ferraz-de-Souza B, da Silva M, Correa P, Nery M . The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus. Diabetol Metab Syndr. 2015; 7:13. PMC: 4351686. DOI: 10.1186/s13098-015-0006-7. View

Levinger I, Jerums G, Stepto N, Parker L, Serpiello F, McConell G . The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men. J Bone Miner Res. 2014; 29(12):2571-6. DOI: 10.1002/jbmr.2285. View

Poole D, Jones A . Measurement of the maximum oxygen uptake V̇o: V̇o is no longer acceptable. J Appl Physiol (1985). 2017; 122(4):997-1002. DOI: 10.1152/japplphysiol.01063.2016. View

Parker L, Lin X, Garnham A, McConell G, Stepto N, Hare D . Glucocorticoid-Induced Insulin Resistance in Men Is Associated With Suppressed Undercarboxylated Osteocalcin. J Bone Miner Res. 2018; 34(1):49-58. DOI: 10.1002/jbmr.3574. View

Clowes J, Robinson R, Heller S, Eastell R, Blumsohn A . Acute changes of bone turnover and PTH induced by insulin and glucose: euglycemic and hypoglycemic hyperinsulinemic clamp studies. J Clin Endocrinol Metab. 2002; 87(7):3324-9. DOI: 10.1210/jcem.87.7.8660. View

Gibala M, Little J, MacDonald M, Hawley J . Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol. 2012; 590(5):1077-84. PMC: 3381816. DOI: 10.1113/jphysiol.2011.224725. View

10.

Levinger I, Seeman E, Jerums G, McConell G, Rybchyn M, Cassar S . Glucose-loading reduces bone remodeling in women and osteoblast function in vitro. Physiol Rep. 2016; 4(3). PMC: 4758933. DOI: 10.14814/phy2.12700. View

11.

Gundberg C, Nieman S, Abrams S, Rosen H . Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab. 1998; 83(9):3258-66. DOI: 10.1210/jcem.83.9.5126. View

12.

Iglesias P, Arrieta F, Pinera M, Botella-Carretero J, Balsa J, Zamarron I . Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance. Clin Endocrinol (Oxf). 2011; 75(2):184-8. DOI: 10.1111/j.1365-2265.2011.04035.x. View

13.

Parfitt A, Travers R, Rauch F, Glorieux F . Structural and cellular changes during bone growth in healthy children. Bone. 2000; 27(4):487-94. DOI: 10.1016/s8756-3282(00)00353-7. View

14.

Levinger I, Brennan-Speranza T, Jerums G, Stepto N, Serpiello F, McConell G . The effect of hyperinsulinaemic-euglycaemic clamp and exercise on bone remodeling markers in obese men. Bonekey Rep. 2015; 4:731. PMC: 4549926. DOI: 10.1038/bonekey.2015.100. View

15.

Mifflin M, St Jeor S, Hill L, Scott B, Daugherty S, Koh Y . A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr. 1990; 51(2):241-7. DOI: 10.1093/ajcn/51.2.241. View

16.

Levinger I, Zebaze R, Jerums G, Hare D, Selig S, Seeman E . The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporos Int. 2010; 22(5):1621-6. DOI: 10.1007/s00198-010-1370-7. View

17.

Lee N, Sowa H, Hinoi E, Ferron M, Ahn J, Confavreux C . Endocrine regulation of energy metabolism by the skeleton. Cell. 2007; 130(3):456-69. PMC: 2013746. DOI: 10.1016/j.cell.2007.05.047. View

18.

Parker L, Trewin A, Levinger I, Shaw C, Stepto N . The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling. PLoS One. 2017; 12(2):e0171613. PMC: 5300197. DOI: 10.1371/journal.pone.0171613. View

19.

Clowes J, Hannon R, Yap T, Hoyle N, Blumsohn A, Eastell R . Effect of feeding on bone turnover markers and its impact on biological variability of measurements. Bone. 2002; 30(6):886-90. DOI: 10.1016/s8756-3282(02)00728-7. View

20.

Fernandez-Real J, Izquierdo M, Ortega F, Gorostiaga E, Gomez-Ambrosi J, Moreno-Navarrete J . The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab. 2008; 94(1):237-45. DOI: 10.1210/jc.2008-0270. View