Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2018 Oct 11

PMID 30302344

Citations 22

Authors

Marco Antonio Hernandez-Luna

Rosendo Luria-Perez

Affiliations

Soon will be listed here.

Abstract

In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising alternative in the fight against cancer. This review describes the role of live attenuated as an oncolytic and immunotherapeutic agent, due to its high affinity for tumor tissue and its ability to activate innate and adaptive antitumor immune response. Furthermore, its potential use as delivery system of tumor antigens and immunomodulatory molecules that induce tumor regression is also reviewed.

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References

Westphal K, Leschner S, Jablonska J, Loessner H, Weiss S . Containment of tumor-colonizing bacteria by host neutrophils. Cancer Res. 2008; 68(8):2952-60. DOI: 10.1158/0008-5472.CAN-07-2984. View

Qian B, Yan F, Li N, Liu Q, Lin Y, Liu C . MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer. Cancer Immunol Immunother. 2011; 60(6):883-93. PMC: 11028919. DOI: 10.1007/s00262-011-0997-3. View

Loeffler M, LeNegrate G, Krajewska M, Reed J . Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth. Proc Natl Acad Sci U S A. 2007; 104(31):12879-83. PMC: 1937560. DOI: 10.1073/pnas.0701959104. View

Miwa S, Yano S, Zhang Y, Matsumoto Y, Uehara F, Yamamoto M . Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget. 2014; 5(16):7119-25. PMC: 4196188. DOI: 10.18632/oncotarget.2226. View

Phan T, Nguyen V, Duong M, Hong Y, Choy H, Min J . Activation of inflammasome by attenuated Salmonella typhimurium in bacteria-mediated cancer therapy. Microbiol Immunol. 2015; 59(11):664-75. DOI: 10.1111/1348-0421.12333. View

Grille S, Moreno M, Brugnini A, Lens D, Chabalgoity J . A therapeutic vaccine using Salmonella-modified tumor cells combined with interleukin-2 induces enhanced antitumor immunity in B-cell lymphoma. Leuk Res. 2012; 37(3):341-8. DOI: 10.1016/j.leukres.2012.10.003. View

Kurashige S, Akuzawa Y, Mitsuhashi S . Synergistic anti-suppressor effect of mini cells prepared from Salmonella typhimurium and mitomycin C in EL 4-bearing mice. Cancer Immunol Immunother. 1985; 19(2):127-9. PMC: 11039077. DOI: 10.1007/BF00199720. View

Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H . Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res. 2009; 29(6):1873-8. View

Yoon W, Chae Y, Hong J, Park Y . Antitumor therapeutic effects of a genetically engineered Salmonella typhimurium harboring TNF-α in mice. Appl Microbiol Biotechnol. 2010; 89(6):1807-19. DOI: 10.1007/s00253-010-3006-4. View

10.

Cao H, Yang Y, Lu L, Liu S, Wang P, Tao X . Attenuated Salmonella typhimurium carrying TRAIL and VP3 genes inhibits the growth of gastric cancer cells in vitro and in vivo. Tumori. 2010; 96(2):296-303. DOI: 10.1177/030089161009600218. View

11.

Stark F, Sad S, Krishnan L . Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection. Cancer Res. 2009; 69(10):4327-34. DOI: 10.1158/0008-5472.CAN-08-3160. View

12.

Spreng S, Dietrich G, Weidinger G . Rational design of Salmonella-based vaccination strategies. Methods. 2006; 38(2):133-43. DOI: 10.1016/j.ymeth.2005.09.012. View

13.

Fensterle J, Bergmann B, Yone C, Hotz C, Meyer S, Spreng S . Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B. Cancer Gene Ther. 2007; 15(2):85-93. DOI: 10.1038/sj.cgt.7701109. View

14.

Germanier R, Fuer E . Isolation and characterization of Gal E mutant Ty 21a of Salmonella typhi: a candidate strain for a live, oral typhoid vaccine. J Infect Dis. 1975; 131(5):553-8. DOI: 10.1093/infdis/131.5.553. View

15.

Saccheri F, Pozzi C, Avogadri F, Barozzi S, Faretta M, Fusi P . Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity. Sci Transl Med. 2010; 2(44):44ra57. DOI: 10.1126/scitranslmed.3000739. View

16.

Kocijancic D, Leschner S, Felgner S, Komoll R, Frahm M, Pawar V . Therapeutic benefit of Salmonella attributed to LPS and TNF-α is exhaustible and dictated by tumor susceptibility. Oncotarget. 2017; 8(22):36492-36508. PMC: 5482671. DOI: 10.18632/oncotarget.16906. View

17.

Spector M, Garcia Del Portillo F, Bearson S, Mahmud A, Magut M, Finlay B . The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimurium. Microbiology (Reading). 1999; 145 ( Pt 11):3035-3045. DOI: 10.1099/00221287-145-11-3035. View

18.

Li K, Qu S, Chen X, Wu Q, Shi M . Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways. Int J Mol Sci. 2017; 18(2). PMC: 5343938. DOI: 10.3390/ijms18020404. View

19.

Wolchok J, Chan T . Cancer: Antitumour immunity gets a boost. Nature. 2014; 515(7528):496-8. PMC: 6592276. DOI: 10.1038/515496a. View

20.

Heimann D, Rosenberg S . Continuous intravenous administration of live genetically modified salmonella typhimurium in patients with metastatic melanoma. J Immunother. 2003; 26(2):179-80. PMC: 2656370. DOI: 10.1097/00002371-200303000-00011. View